Yuichi Sugiyama
Tokyo, Japan
Last Updated: 09/26/2026
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Found 389 publications
Net Renal Drug Secretion Critically Requires Significant Contribution of Basal Uptake Transporters: Perspective From Mechanistic Kidney Model Simulation and Integration of Clinical and In Vitro Data.
Journal: CPT: pharmacometrics & systems pharmacology
Published: March 11, 2026
Mechanistic insights into edoxaban's nonlinear pharmacokinetics and quinidine interaction via P-glycoprotein using physiologically based pharmacokinetic modeling.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: December 03, 2025
Characterizing Apixaban Pharmacokinetics Through Physiologically-Based Pharmacokinetic Modeling: Critical Role of Biliary Secretion and Enterohepatic Circulation in Humans.
Journal: CPT: pharmacometrics & systems pharmacology
Published: August 04, 2025
Simultaneous Target-Mediated Drug Disposition-Pharmacodynamic (TMDD-PD) Modeling of Finasteride and Dutasteride: Impact of Target Binding and Turnover on Non-linear Pharmacokinetics.
Journal: The AAPS journal
Published: May 17, 2025
Predicting OCT2/MATEs-Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium).
Journal: Clinical pharmacology and therapeutics
Published: January 13, 2025
Bridging in vitro and clinical data: Experimental insights into the IC50 variability of dolutegravir as an organic cation transporter 2 inhibitor.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: January 09, 2025
Elucidating Contributions of Drug Transporters/Enzyme to Nonlinear Pharmacokinetics of Grazoprevir by PBPK Modeling With a Cluster Gauss-Newton Method.
Journal: CPT: pharmacometrics & systems pharmacology
Published: October 04, 2024
Trends of in vitro pharmacological potency and in vivo pharmacokinetics parameters of modern drugs: Can the therapeutic/subtherapeutic dose be estimated from in vitro Ki and pharmacokinetic parameters?
Journal: Clinical and translational science
Published: June 30, 2024
Elucidation of DPP-4 involvement in systemic distribution and renal reabsorption of linagliptin by PBPK modeling with a cluster Gauss-Newton method.
Journal: Clinical and translational science
Published: June 30, 2024
Effects of Cimetidine and Dolutegravir on the Endogenous Drug-Drug Interaction Biomarkers for Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Protein 1 in Healthy Volunteers.
Journal: Clinical pharmacology and therapeutics
Published: June 27, 2024
Editorial: Incorporating Phase 0 microdosing as a powerful tool into a new vision of drug development.
Journal: Frontiers in pharmacology
Published: June 27, 2024
Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target-mediated drug disposition and OATP1B3-mediated hepatic uptake in a physiologically based model.
Journal: CPT: pharmacometrics & systems pharmacology
Published: January 10, 2024
Last Updated: 09/26/2026