Yuichiro Higuchi
Kanagawa, Japan
Last Updated: 09/26/2026
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Found 53 publications
Chromobox 4 interacts with pregnane X receptor to repress CYP3A4 expression through polycomb repressive complex 1/2-mediated epigenetic regulation.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: March 30, 2026
CYP1A2 and ADH1C contribute to abacavir aldehyde intermediate formation in the human liver.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: March 23, 2026
Nucleolar and coiled-body phosphoprotein 1 enhances the induction of CYP3A4 by promoting nuclear translocation of pregnane X receptor.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: March 20, 2026
Correction: Development of a DNA damage assay system using stable human hepatocytes.
Journal: Genes and environment : the official journal of the Japanese Environmental Mutagen Society
Published: March 02, 2026
Baseline variations in in vivo cytochrome P450 3A-dependent phenotypes evaluated using concentrations of endogenous or deuterium-labeled cortisol and their 6β-hydroxylated metabolites in 103 cynomolgus monkeys and 20 humanized-liver mice transplanted with hepatocytes.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: February 05, 2026
Regulatory impact of G-quadruplexes in the human carboxylesterase 2 gene on drug and lipid metabolism.
Journal: Drug metabolism and pharmacokinetics
Published: January 05, 2026
Humanized-liver TK-NOG mice lacking plasma carboxylesterase 1c improve the prediction of human carboxylesterase 1-mediated drug metabolism.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: December 25, 2025
Application of HepaSH cells for predicting cholestatic drug-induced liver injury via bile acid-dependent toxicity assay.
Journal: Drug metabolism and pharmacokinetics
Published: November 16, 2025
Development of a DNA damage assay system using stable human hepatocytes.
Journal: Genes and environment : the official journal of the Japanese Environmental Mutagen Society
Published: October 03, 2025
Derivation of embryonic stem cells from cloned blastocysts using improved somatic cell nuclear transfer in common marmosets.
Journal: Stem cell reports
Published: August 22, 2025
Prediction of human hepatic clearance with HepaSH monolayers for low-turnover compounds.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: July 09, 2025
Last Updated: 09/26/2026