Yukihiro Itoh

Tokyo, Japan

Last Updated: 09/26/2026

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Found 69 publications

Development of Protein and RNA Degraders for Drug Discovery

Development of Protein and RNA Degraders for Drug Discovery

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

Published: July 01, 2026

Advances in Targeted Protein Degradation Technology

Advances in Targeted Protein Degradation Technology

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

Published: July 01, 2026

Theoretical study on N(sp2)+-C(sp2)-H···O hydrogen bonds in the context of drug discovery.

Theoretical study on N(sp2)+-C(sp2)-H···O hydrogen bonds in the context of drug discovery.

Journal: Scientific reports

Published: May 15, 2026

Identification of non-hydroxamate histone deacetylase 8 inhibitors using deep learning-based screening of two-dimensional molecular images.

Identification of non-hydroxamate histone deacetylase 8 inhibitors using deep learning-based screening of two-dimensional molecular images.

Journal: Bioorganic & medicinal chemistry

Published: April 02, 2026

Targeted Degradation of Histone Deacetylase 8 Using Proteolysis Targeting Chimeras Technology: A Promising Approach for Glioblastoma Treatment.

Targeted Degradation of Histone Deacetylase 8 Using Proteolysis Targeting Chimeras Technology: A Promising Approach for Glioblastoma Treatment.

Journal: Drug design, development and therapy

Published: September 19, 2025

A Novel PROTAC G9a/GLP Degrader that Inhibits, Similar to G9a siRNA, the Migration of MCF-7 Breast-Cancer Cells without Affecting Proliferation.

A Novel PROTAC G9a/GLP Degrader that Inhibits, Similar to G9a siRNA, the Migration of MCF-7 Breast-Cancer Cells without Affecting Proliferation.

Journal: Journal of medicinal chemistry

Published: August 31, 2025

Identification of a novel small-molecule inhibitor of heterochromatin protein 1.

Identification of a novel small-molecule inhibitor of heterochromatin protein 1.

Journal: Bioorganic & medicinal chemistry letters

Published: July 24, 2025

A Deep-Learning-Aided Drug Screening Based on Visualization of a Hidden Layer as Chemical Space.

A Deep-Learning-Aided Drug Screening Based on Visualization of a Hidden Layer as Chemical Space.

Journal: ACS medicinal chemistry letters

Published: March 06, 2025

Epigenetic Inhibitors as Alzheimer's Disease Therapeutic Agents.

Epigenetic Inhibitors as Alzheimer's Disease Therapeutic Agents.

Journal: Chemical & pharmaceutical bulletin

Published: June 30, 2024

Identification of Proteolysis Targeting Chimeras (PROTACs) for Lysine Demethylase 5 and Their Neurite Outgrowth-Promoting Activity.

Identification of Proteolysis Targeting Chimeras (PROTACs) for Lysine Demethylase 5 and Their Neurite Outgrowth-Promoting Activity.

Journal: Chemical & pharmaceutical bulletin

Published: June 30, 2024

Identification of a novel histone H2A mono-ubiquitination-inhibiting cell-active small molecule.

Identification of a novel histone H2A mono-ubiquitination-inhibiting cell-active small molecule.

Journal: Bioorganic & medicinal chemistry letters

Published: February 27, 2024

Identification of a Histone Deacetylase 8 Inhibitor through Drug Screenings Based on Machine Learning.

Identification of a Histone Deacetylase 8 Inhibitor through Drug Screenings Based on Machine Learning.

Journal: Chemical & pharmaceutical bulletin

Published: January 31, 2024

Showing 1-12 of 69

Last Updated: 09/26/2026