Yumi Cleary
Basel, BS, Switzerland
Last Updated: 09/26/2026
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Found 18 publications
Population Physiologically-Based Pharmacokinetic Modeling to Determine Ontogeny: A Quantitative Clinical Pharmacology Example in Pediatric Rare Disease.
Journal: CPT: pharmacometrics & systems pharmacology
Published: June 28, 2025
Simultaneous Estimation of fm and FG Values Directly from Clinical Drug-Drug Interaction Study Data.
Simultaneous Estimation of fm and FG Values Directly from Clinical Drug-Drug Interaction Study Data.
Journal: The AAPS journal
Published: December 06, 2024
Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug-Drug Interactions in Children.
Journal: Clinical pharmacokinetics
Published: March 19, 2023
Accelerating Clinical Development of Idasanutlin through a Physiologically Based Pharmacokinetic Modeling Risk Assessment for CYP450 Isoenzyme-Related Drug-Drug Interactions.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: October 08, 2021
Physiologically-Based Pharmacokinetic Modelling of Entrectinib Parent and Active Metabolite to Support Regulatory Decision-Making.
Journal: European journal of drug metabolism and pharmacokinetics
Published: August 17, 2021
Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: June 03, 2021
Model-Based Drug-Drug Interaction Extrapolation Strategy From Adults to Children: Risdiplam in Pediatric Patients With Spinal Muscular Atrophy.
Journal: Clinical pharmacology and therapeutics
Published: March 24, 2021
Effect of Hepatic Impairment on the Pharmacokinetics of Alectinib.
Journal: Journal of clinical pharmacology
Published: April 26, 2018
A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier.
Journal: British journal of clinical pharmacology
Published: March 23, 2018
Development of a physiologically based pharmacokinetic model for mefloquine and its application alongside a clinical effectiveness model to select an optimal dose for prevention of malaria in young Caucasian children.
Journal: British journal of clinical pharmacology
Published: March 21, 2018
Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective.
Journal: Clinical pharmacology and therapeutics
Published: November 07, 2017
Last Updated: 09/26/2026