Yumi Yamamoto

Leiden, ZH, Netherlands

Last Updated: 09/26/2026

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Found 13 publications

Quantitative relationship between tominersen concentrations in cerebrospinal fluid and biomarker changes in Huntington's disease patients.

Quantitative relationship between tominersen concentrations in cerebrospinal fluid and biomarker changes in Huntington's disease patients.

Journal: British journal of clinical pharmacology

Published: June 10, 2025

Modeling Disease Progression and Placebo Response in Huntington Disease: Insights From Enroll-HD and GENERATION HD1 Cohorts.

Modeling Disease Progression and Placebo Response in Huntington Disease: Insights From Enroll-HD and GENERATION HD1 Cohorts.

Journal: Neurology

Published: May 02, 2025

Development of a population pharmacokinetic model to characterize the pharmacokinetics of intrathecally administered tominersen in cerebrospinal fluid and plasma.

Development of a population pharmacokinetic model to characterize the pharmacokinetics of intrathecally administered tominersen in cerebrospinal fluid and plasma.

Journal: CPT: pharmacometrics & systems pharmacology

Published: January 02, 2023

Ocrelizumab in relapsing and primary progressive multiple sclerosis: Pharmacokinetic and pharmacodynamic analyses of OPERA I, OPERA II and ORATORIO.

Ocrelizumab in relapsing and primary progressive multiple sclerosis: Pharmacokinetic and pharmacodynamic analyses of OPERA I, OPERA II and ORATORIO.

Journal: British journal of clinical pharmacology

Published: September 09, 2019

Combining Brain Microdialysis and Translational Pharmacokinetic Modeling to Predict Drug Concentrations in Pediatric Severe Traumatic Brain Injury: The Next Step Toward Evidence-Based Pharmacotherapy?

Combining Brain Microdialysis and Translational Pharmacokinetic Modeling to Predict Drug Concentrations in Pediatric Severe Traumatic Brain Injury: The Next Step Toward Evidence-Based Pharmacotherapy?

Journal: Journal of neurotrauma

Published: July 19, 2018

Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics.

Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics.

Journal: Expert opinion on drug discovery

Published: September 22, 2017

Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach.

Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: September 07, 2017

Analgosedation in paediatric severe traumatic brain injury (TBI): practice, pitfalls and possibilities.

Analgosedation in paediatric severe traumatic brain injury (TBI): practice, pitfalls and possibilities.

Journal: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Published: June 28, 2017

Erratum to: Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations.

Erratum to: Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations.

Journal: The AAPS journal

Published: May 11, 2017

Predicting Drug Concentration-Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically-Based Pharmacokinetic Model.

Predicting Drug Concentration-Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically-Based Pharmacokinetic Model.

Journal: CPT: pharmacometrics & systems pharmacology

Published: April 03, 2017

Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations.

Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations.

Journal: The AAPS journal

Published: November 22, 2016

A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations.

A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations.

Journal: Pharmaceutical research

Published: August 24, 2016

Showing 1-12 of 13

Last Updated: 09/26/2026