Yunlei J. Hou

103 Wenhua Road, Shenhe District
Shenyang, 110016, China

Last Updated: 09/26/2026

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Found 49 publications

Identification of 2,4-Diaminopyrimidine Derivatives as Novel Gut-Restricted Selective JAK1 Inhibitors for the Treatment of Inflammatory Bowel Disease.

Identification of 2,4-Diaminopyrimidine Derivatives as Novel Gut-Restricted Selective JAK1 Inhibitors for the Treatment of Inflammatory Bowel Disease.

Journal: Journal of medicinal chemistry

Published: February 24, 2026

Design, synthesis, and evaluation of dual-target inhibitors of acetylcholinesterase (AChE) and soluble epoxide hydrolase (sEH) for the treatment of Alzheimer's disease.

Design, synthesis, and evaluation of dual-target inhibitors of acetylcholinesterase (AChE) and soluble epoxide hydrolase (sEH) for the treatment of Alzheimer's disease.

Journal: European journal of medicinal chemistry

Published: February 12, 2026

Design, synthesis and biological activity evaluation of a novel selective inhibitor in PLK1 with acyl or sulfonyl substituted dihydroindole structure.

Design, synthesis and biological activity evaluation of a novel selective inhibitor in PLK1 with acyl or sulfonyl substituted dihydroindole structure.

Journal: Bioorganic chemistry

Published: November 02, 2025

Multiparameter Optimization of Broad-Spectrum Antibacterial Activity, ADMET Properties, and MAO-A/B Inhibition of Novel Biaryloxazolidinone-Hydrazone Derivatives: Identification of a Lead with In Vivo Efficacy against Linezolid-Resistant Staphylococcus aureus.

Multiparameter Optimization of Broad-Spectrum Antibacterial Activity, ADMET Properties, and MAO-A/B Inhibition of Novel Biaryloxazolidinone-Hydrazone Derivatives: Identification of a Lead with In Vivo Efficacy against Linezolid-Resistant Staphylococcus aureus.

Journal: Journal of medicinal chemistry

Published: August 15, 2025

Small-molecule FGFR-targeted medicinal chemistry: Advances since 2020 and future perspectives.

Small-molecule FGFR-targeted medicinal chemistry: Advances since 2020 and future perspectives.

Journal: European journal of medicinal chemistry

Published: July 30, 2025

Inverse Agonists of Peroxisome Proliferator-Activated Receptor Gamma: Advances and Prospects in Cancer Treatment.

Inverse Agonists of Peroxisome Proliferator-Activated Receptor Gamma: Advances and Prospects in Cancer Treatment.

Journal: Journal of medicinal chemistry

Published: April 29, 2025

Design, synthesis and biological evaluation of novel 4-(thieno[3,2-d]pyrimidin-4-yl)morpholine derivatives as potent antitumor agents.

Design, synthesis and biological evaluation of novel 4-(thieno[3,2-d]pyrimidin-4-yl)morpholine derivatives as potent antitumor agents.

Journal: European journal of medicinal chemistry

Published: March 01, 2025

Design, synthesis, and biological evaluation of 2,4-diaminopyrimidine inhibitors of hematopoietic progenitor kinase 1.

Design, synthesis, and biological evaluation of 2,4-diaminopyrimidine inhibitors of hematopoietic progenitor kinase 1.

Journal: Bioorganic & medicinal chemistry letters

Published: January 05, 2025

Discovery of novel dihydropteridone derivatives as orally bioavailable PLK1 inhibitors with reduced hERG inhibitory activity for acute myeloid leukemia treatment.

Discovery of novel dihydropteridone derivatives as orally bioavailable PLK1 inhibitors with reduced hERG inhibitory activity for acute myeloid leukemia treatment.

Journal: European journal of medicinal chemistry

Published: December 31, 2024

Design, synthesis and evaluation of novel LpxC inhibitors containing a hydrazone moiety as Gram-negative antibacterial agents.

Design, synthesis and evaluation of novel LpxC inhibitors containing a hydrazone moiety as Gram-negative antibacterial agents.

Journal: European journal of medicinal chemistry

Published: July 26, 2024

Dual-target inhibitors based on acetylcholinesterase: Novel agents for Alzheimer's disease.

Dual-target inhibitors based on acetylcholinesterase: Novel agents for Alzheimer's disease.

Journal: European journal of medicinal chemistry

Published: July 15, 2024

Identification of novel PD-1/PD-L1 small molecule inhibitors: virtual screening, synthesis and in vitro characterisation.

Identification of novel PD-1/PD-L1 small molecule inhibitors: virtual screening, synthesis and in vitro characterisation.

Journal: Journal of enzyme inhibition and medicinal chemistry

Published: June 18, 2024

Showing 1-12 of 49

Last Updated: 09/26/2026