Yunxiao Zhang

Rongjiawan, 414006, China

Last Updated: 09/26/2026

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Found 19 publications

Novel design of interleukin-2 derivatives with reversed pH and potent antitumor activity.

Novel design of interleukin-2 derivatives with reversed pH and potent antitumor activity.

Journal: European journal of medicinal chemistry

Published: January 25, 2026

A Sequential Dual GLP-1R/GIPR Agonist-To-Antagonist Molecule Achieves Superior Weight Loss in Obese Mice.

A Sequential Dual GLP-1R/GIPR Agonist-To-Antagonist Molecule Achieves Superior Weight Loss in Obese Mice.

Journal: Diabetes, obesity & metabolism

Published: January 17, 2026

Structural basis for inhibition of the voltage-gated sodium channel NaV1.7 by the tarantula toxin HWTX-I.

Structural basis for inhibition of the voltage-gated sodium channel NaV1.7 by the tarantula toxin HWTX-I.

Journal: The Journal of biological chemistry

Published: November 07, 2025

Novel design of potent anti-tumour activity of IL-2 prodrug by FAPα-mediated activation.

Novel design of potent anti-tumour activity of IL-2 prodrug by FAPα-mediated activation.

Journal: International journal of biological macromolecules

Published: June 28, 2024

Optimizing Nav1.7-Targeted Analgesics: Revealing Off-Target Effects of Spider Venom-Derived Peptide Toxins and Engineering Strategies for Improvement.

Optimizing Nav1.7-Targeted Analgesics: Revealing Off-Target Effects of Spider Venom-Derived Peptide Toxins and Engineering Strategies for Improvement.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Published: June 16, 2024

A two-step method preparation of semaglutide through solid-phase synthesis and inclusion body expression.

A two-step method preparation of semaglutide through solid-phase synthesis and inclusion body expression.

Journal: Protein expression and purification

Published: January 12, 2024

A novel ω-conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity.

A novel ω-conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity.

Journal: Acta pharmaceutica Sinica. B

Published: December 21, 2020

Engineering of highly potent and selective HNTX-III mutant against hNav1.7 sodium channel for treatment of pain.

Engineering of highly potent and selective HNTX-III mutant against hNav1.7 sodium channel for treatment of pain.

Journal: The Journal of biological chemistry

Published: October 17, 2020

Recombinant PaurTx-3, a spider toxin, inhibits sodium channels and decreases membrane excitability in DRG neurons.

Recombinant PaurTx-3, a spider toxin, inhibits sodium channels and decreases membrane excitability in DRG neurons.

Journal: Biochemical and biophysical research communications

Published: September 07, 2020

Naja atra venom peptide reduces pain by selectively blocking the voltage-gated sodium channel Nav1.8.

Naja atra venom peptide reduces pain by selectively blocking the voltage-gated sodium channel Nav1.8.

Journal: The Journal of biological chemistry

Published: December 31, 2018

Engineering Gain-of-Function Analogues of the Spider Venom Peptide HNTX-I, A Potent Blocker of the hNaV1.7 Sodium Channel.

Engineering Gain-of-Function Analogues of the Spider Venom Peptide HNTX-I, A Potent Blocker of the hNaV1.7 Sodium Channel.

Journal: Toxins

Published: August 03, 2018

Discovery of a Novel Nav1.7 Inhibitor From Cyriopagopus albostriatus Venom With Potent Analgesic Efficacy.

Discovery of a Novel Nav1.7 Inhibitor From Cyriopagopus albostriatus Venom With Potent Analgesic Efficacy.

Journal: Frontiers in pharmacology

Published: July 12, 2018

Showing 1-12 of 19

Last Updated: 09/26/2026