Zelan Hu

School Of Pharmacy East China University Of Science And Technology 130 Meilong Road
Meilong, 200237, China

Last Updated: 09/26/2026

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Found 17 publications

Discovery of Novel MDH2 Inhibitor 28i by Secondary Development of Glibenclamide with Potent Antiaging Activities.

Discovery of Novel MDH2 Inhibitor 28i by Secondary Development of Glibenclamide with Potent Antiaging Activities.

Journal: Journal of medicinal chemistry
Published: January 23, 2026

Purification, structural characterization, and anti-ulcerative colitis activity of a novel pectin-like polysaccharide AH-H4-1 from Alhagi honey.

Purification, structural characterization, and anti-ulcerative colitis activity of a novel pectin-like polysaccharide AH-H4-1 from Alhagi honey.

Journal: International journal of biological macromolecules
Published: February 28, 2025

Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification.

Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification.

Journal: Signal transduction and targeted therapy
Published: August 23, 2024

Nicandra physalodes Extract Exerts Antiaging Effects in Multiple Models and Extends the Lifespan of Caenorhabditis elegans via DAF-16 and HSF-1.

Nicandra physalodes Extract Exerts Antiaging Effects in Multiple Models and Extends the Lifespan of Caenorhabditis elegans via DAF-16 and HSF-1.

Journal: Oxidative medicine and cellular longevity
Published: June 12, 2022

Conditional ablation of protein tyrosine phosphatase receptor U in midbrain dopaminergic neurons results in reduced neuronal size.

Conditional ablation of protein tyrosine phosphatase receptor U in midbrain dopaminergic neurons results in reduced neuronal size.

Journal: Journal of chemical neuroanatomy
Published: January 28, 2022

Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9.

Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9.

Journal: eLife
Published: September 19, 2021

Characterization of cellular senescence in doxorubicin-induced aging mice.

Characterization of cellular senescence in doxorubicin-induced aging mice.

Journal: Experimental gerontology
Published: August 16, 2021

First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase.

First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase.

Journal: Chemical science
Published: June 14, 2021

Anti-aging effects of chlorpropamide depend on mitochondrial complex-II and the production of mitochondrial reactive oxygen species.

Anti-aging effects of chlorpropamide depend on mitochondrial complex-II and the production of mitochondrial reactive oxygen species.

Journal: Acta pharmaceutica Sinica. B
Published: May 23, 2021

Antiaging Effects of Vicatia thibetica de Boiss Root Extract on Caenorhabditis elegans and Doxorubicin-Induced Premature Aging in Adult Mice.

Antiaging Effects of Vicatia thibetica de Boiss Root Extract on Caenorhabditis elegans and Doxorubicin-Induced Premature Aging in Adult Mice.

Journal: Oxidative medicine and cellular longevity
Published: March 16, 2021

Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy.

Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy.

Journal: Aging
Published: September 07, 2019

Lactose induced redox-dependent senescence and activated Nrf2 pathway.

Lactose induced redox-dependent senescence and activated Nrf2 pathway.

Journal: International journal of clinical and experimental pathology
Published: March 05, 2019
Showing 1-12 of 17

Last Updated: 09/26/2026