Zhaoxing X. Chu

Hefei, China

Last Updated: 09/26/2026

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Found 30 publications

Development and Validation of an LC-MS/MS Method for the Quantification of HY-078020 in Human Plasma Using Liquid-Liquid Extraction and Its Application to Human Pharmacokinetic Study.

Development and Validation of an LC-MS/MS Method for the Quantification of HY-078020 in Human Plasma Using Liquid-Liquid Extraction and Its Application to Human Pharmacokinetic Study.

Journal: Biomedical chromatography : BMC

Published: May 07, 2026

Discovery of Highly Potent Phthalazinone Derivatives as PARP14 Inhibitors: From Structure-Based Virtual Screening to In Vivo Pharmacodynamic Activity.

Discovery of Highly Potent Phthalazinone Derivatives as PARP14 Inhibitors: From Structure-Based Virtual Screening to In Vivo Pharmacodynamic Activity.

Journal: Journal of medicinal chemistry

Published: April 20, 2026

Virtual bioequivalence-guided PBBM prediction for ibuprofen/diphenhydramine citrate tablets: impact of dissolution variability and clinical standard development.

Virtual bioequivalence-guided PBBM prediction for ibuprofen/diphenhydramine citrate tablets: impact of dissolution variability and clinical standard development.

Journal: Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Published: January 30, 2026

In vitro and ex vivo Pharmacological Profile of HY-022619, a Novel Intravenous P2Y12 Receptor Antagonist with Rapid-onset and Sustained Antiplatelet Activity.

In vitro and ex vivo Pharmacological Profile of HY-022619, a Novel Intravenous P2Y12 Receptor Antagonist with Rapid-onset and Sustained Antiplatelet Activity.

Journal: Pharmaceutical research

Published: December 11, 2025

Discovery of a spirocyclic influenza RNA-dependent RNA polymerase inhibitor.

Discovery of a spirocyclic influenza RNA-dependent RNA polymerase inhibitor.

Journal: Bioorganic chemistry

Published: August 14, 2025

Novel 3-n-butylphthalide derivatives as potent multi-functional anti-IS agents with BBB protective function.

Novel 3-n-butylphthalide derivatives as potent multi-functional anti-IS agents with BBB protective function.

Journal: Bioorganic chemistry

Published: August 13, 2025

Safety, pharmacokinetics, and efficacy of HY-072808 ointment, a novel PDE4 inhibitor, in adolescent and adult patients with mild-to-moderate AD.

Safety, pharmacokinetics, and efficacy of HY-072808 ointment, a novel PDE4 inhibitor, in adolescent and adult patients with mild-to-moderate AD.

Journal: Expert opinion on investigational drugs

Published: May 24, 2025

HY-021068 improves neuronal ferroptosis by activating Nrf2 signaling in APP/PS1 Mice and Aβ1-42-induced HT22 cells.

HY-021068 improves neuronal ferroptosis by activating Nrf2 signaling in APP/PS1 Mice and Aβ1-42-induced HT22 cells.

Journal: European journal of pharmacology

Published: May 14, 2025

Discovery and Optimization of Potent and Highly Selective PARP14 Inhibitors for the Treatment of Atopic Dermatitis.

Discovery and Optimization of Potent and Highly Selective PARP14 Inhibitors for the Treatment of Atopic Dermatitis.

Journal: Journal of medicinal chemistry

Published: April 16, 2025

Successive structural optimization of Ziritaxestat culminates in the discovery of orally bioavailable and in vivo potent imidazothiadiazole derivative for treating ATX-driven diseases.

Successive structural optimization of Ziritaxestat culminates in the discovery of orally bioavailable and in vivo potent imidazothiadiazole derivative for treating ATX-driven diseases.

Journal: European journal of medicinal chemistry

Published: April 06, 2025

Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-MS/MS method.

Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-MS/MS method.

Journal: Xenobiotica; the fate of foreign compounds in biological systems

Published: March 19, 2024

Design, Synthesis, and Biological Evaluation of Pierardine Derivatives as Novel Brain-Penetrant and In Vivo Potent NMDAR-GluN2B Antagonists for Ischemic Stroke Treatment.

Design, Synthesis, and Biological Evaluation of Pierardine Derivatives as Novel Brain-Penetrant and In Vivo Potent NMDAR-GluN2B Antagonists for Ischemic Stroke Treatment.

Journal: Journal of medicinal chemistry

Published: February 27, 2024

Showing 1-12 of 30

Last Updated: 09/26/2026