Zheng-yu Jiang

Jiangsu Key Laboratory Of Drug Design And Optimization
Nanjing, 210009, China

Last Updated: 09/26/2026

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Found 50 publications

Identification of Pyrrolo [2,3-b] Pyridine Derivatives as Novel JAK1 Inhibitors for the Treatment of Inflammatory Bowel Disease.

Identification of Pyrrolo [2,3-b] Pyridine Derivatives as Novel JAK1 Inhibitors for the Treatment of Inflammatory Bowel Disease.

Journal: Molecules (Basel, Switzerland)

Published: May 28, 2026

Development of highly selective, low-toxicity and orally available Mcl-1 inhibitors based on 3,5-dimethyl-4-sulfonimide-1H-pyrrole scaffold via P2/P3 dual pocket binding optimization.

Development of highly selective, low-toxicity and orally available Mcl-1 inhibitors based on 3,5-dimethyl-4-sulfonimide-1H-pyrrole scaffold via P2/P3 dual pocket binding optimization.

Journal: European journal of medicinal chemistry

Published: April 07, 2026

Nuclear factor erythroid 2-related factor 2 (Nrf2) inhibition revisited: advances and unmet challenges.

Nuclear factor erythroid 2-related factor 2 (Nrf2) inhibition revisited: advances and unmet challenges.

Journal: Journal of advanced research

Published: December 31, 2025

Discovery of an allosteric 14-3-3 inhibitor for suppressing NRF2-driven cancer via phenotypic screening and chemoproteomic-based target deconvolution.

Discovery of an allosteric 14-3-3 inhibitor for suppressing NRF2-driven cancer via phenotypic screening and chemoproteomic-based target deconvolution.

Journal: Chemical science

Published: June 12, 2025

Discovery of Novel Tofacitinib-ADTOH Molecular Hybridization Derivatives for the Treatment of Ulcerative Colitis.

Discovery of Novel Tofacitinib-ADTOH Molecular Hybridization Derivatives for the Treatment of Ulcerative Colitis.

Journal: Antioxidants (Basel, Switzerland)

Published: February 06, 2025

Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitors for ulcerative colitis management.

Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitors for ulcerative colitis management.

Journal: European journal of medicinal chemistry

Published: December 20, 2024

Discovery and Development of Caffeic Acid Analogs as Versatile Therapeutic Agents.

Discovery and Development of Caffeic Acid Analogs as Versatile Therapeutic Agents.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: September 09, 2024

Discovery of Pyrazolo[1,5-a]pyrimidine Derivative as a Novel and Selective ALKBH5 Inhibitor for the Treatment of AML.

Discovery of Pyrazolo[1,5-a]pyrimidine Derivative as a Novel and Selective ALKBH5 Inhibitor for the Treatment of AML.

Journal: Journal of medicinal chemistry

Published: November 20, 2023

Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor.

Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor.

Journal: Journal of medicinal chemistry

Published: April 07, 2023

Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome.

Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome.

Journal: Journal of medicinal chemistry

Published: March 07, 2022

Discovery of 2-((2-methylbenzyl)thio)-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of sepsis.

Discovery of 2-((2-methylbenzyl)thio)-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of sepsis.

Journal: European journal of medicinal chemistry

Published: March 04, 2022

Proteolysis-targeting chimeras: a kaleidoscope of targeted protein degradation.

Proteolysis-targeting chimeras: a kaleidoscope of targeted protein degradation.

Journal: Future medicinal chemistry

Published: November 24, 2021

Showing 1-12 of 50

Last Updated: 09/26/2026