Zhengchao F. Tu

190 Kaiyuan Avenue, Guangzhou Science Park
Guangzhou, 510530, China

Last Updated: 09/26/2026

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Found 110 publications

Structure-Based Design of 4-(1-Methyl-1H-indol-3-yl)pyrimidin-2-amine Derivatives as the First Covalent FGFR3 Selective Inhibitors.

Structure-Based Design of 4-(1-Methyl-1H-indol-3-yl)pyrimidin-2-amine Derivatives as the First Covalent FGFR3 Selective Inhibitors.

Journal: Journal of medicinal chemistry

Published: February 06, 2026

Design, Synthesis, and Biological Evaluation of the First Novel Macrocycle-Based FGFR Inhibitors That Overcome Clinically Acquired Resistance.

Design, Synthesis, and Biological Evaluation of the First Novel Macrocycle-Based FGFR Inhibitors That Overcome Clinically Acquired Resistance.

Journal: Journal of medicinal chemistry

Published: January 06, 2026

Design, Synthesis and Biological Evaluation of 7-(1-Methyl-1H-indole-3-yl)-5H-pyrrolo[2,3-b]pyrazine Derivatives as Novel Covalent pan-FGFR Inhibitors to Overcome Clinical Resistance.

Design, Synthesis and Biological Evaluation of 7-(1-Methyl-1H-indole-3-yl)-5H-pyrrolo[2,3-b]pyrazine Derivatives as Novel Covalent pan-FGFR Inhibitors to Overcome Clinical Resistance.

Journal: Journal of medicinal chemistry

Published: September 08, 2025

Enhancing Drug Repurposing with Consensus Docking: Discovery of Novel Discoidin Domain Receptor 1 Inhibitors.

Enhancing Drug Repurposing with Consensus Docking: Discovery of Novel Discoidin Domain Receptor 1 Inhibitors.

Journal: ChemMedChem

Published: September 01, 2025

Optimization of Novel Quinazolines as Potent Aurora Kinase Inhibitors for Triple-Negative Breast Cancer Treatment.

Optimization of Novel Quinazolines as Potent Aurora Kinase Inhibitors for Triple-Negative Breast Cancer Treatment.

Journal: Journal of medicinal chemistry

Published: August 25, 2025

High-Resolution Neuraminidase Inhibition Profiling of Synsepalum Dulcificum Based on UPLC-MS/MS: A Study of Anti-Influenza Constituents in a Potential Edible Resource.

High-Resolution Neuraminidase Inhibition Profiling of Synsepalum Dulcificum Based on UPLC-MS/MS: A Study of Anti-Influenza Constituents in a Potential Edible Resource.

Journal: Journal of food science

Published: August 16, 2025

DDX27: An RNA helicase regulating cancer progression and therapeutic prospects.

DDX27: An RNA helicase regulating cancer progression and therapeutic prospects.

Journal: International journal of biological macromolecules

Published: April 13, 2025

Designing Macrocyclic Kinase Inhibitors Using Macrocycle Scaffold Hopping with Reinforced Learning (Macro-Hop).

Designing Macrocyclic Kinase Inhibitors Using Macrocycle Scaffold Hopping with Reinforced Learning (Macro-Hop).

Journal: Journal of medicinal chemistry

Published: March 18, 2025

Natural Lignan Vitexin B-1 Induces Cell Cycle Arrest and Apoptosis via Targeting HSP90 Through EGFR Pathway in Non-Small Cell Lung Cancer.

Natural Lignan Vitexin B-1 Induces Cell Cycle Arrest and Apoptosis via Targeting HSP90 Through EGFR Pathway in Non-Small Cell Lung Cancer.

Journal: Journal of biochemical and molecular toxicology

Published: January 10, 2025

Synthesis and anti-influenza virus activity of substituted dibenzoxepine-based baloxavir derivatives.

Synthesis and anti-influenza virus activity of substituted dibenzoxepine-based baloxavir derivatives.

Journal: European journal of medicinal chemistry

Published: July 18, 2024

Synthesis and biological evaluation of novel isobenzofuran-1(3H)-one derivatives as antidepressant agents.

Synthesis and biological evaluation of novel isobenzofuran-1(3H)-one derivatives as antidepressant agents.

Journal: Bioorganic & medicinal chemistry

Published: June 28, 2024

Design, synthesis and biological evaluation of 5-amino-1H-pyrazole-4-carboxamide derivatives as pan-FGFR covalent inhibitors.

Design, synthesis and biological evaluation of 5-amino-1H-pyrazole-4-carboxamide derivatives as pan-FGFR covalent inhibitors.

Journal: European journal of medicinal chemistry

Published: April 10, 2024

Showing 1-12 of 110

Last Updated: 09/26/2026