Zhenjiang M. Zhao

State Key Laboratory Of Bioreactor Engineering
Shanghai, 200237, China

Last Updated: 09/26/2026

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Found 80 publications

RingKin: portraying the vast macrocyclic chemical universe surrounding kinase drugs.

RingKin: portraying the vast macrocyclic chemical universe surrounding kinase drugs.

Journal: Chemical science

Published: May 15, 2026

Discovery of 1,2-Diol TRPV4 Antagonists with Efficacy in a 3D Myocardial Fibrosis Organoid Model and a Murine TAC Pressure-Overload Model.

Discovery of 1,2-Diol TRPV4 Antagonists with Efficacy in a 3D Myocardial Fibrosis Organoid Model and a Murine TAC Pressure-Overload Model.

Journal: Journal of medicinal chemistry

Published: May 14, 2026

Rational Design, Synthesis, and Biological Evaluation of Potent, Highly Selective 1,2,4-Oxadiazole-Based S1PR1 Agonists for UC Treatment.

Rational Design, Synthesis, and Biological Evaluation of Potent, Highly Selective 1,2,4-Oxadiazole-Based S1PR1 Agonists for UC Treatment.

Journal: Journal of medicinal chemistry

Published: April 17, 2026

The mechanism of Rap1GAP in ventricular hypertrophy and interstitial fibrosis induced by angiotensin Ⅱ

The mechanism of Rap1GAP in ventricular hypertrophy and interstitial fibrosis induced by angiotensin Ⅱ

Journal: Zhonghua xin xue guan bing za zhi

Published: March 22, 2026

Discovery of novel CSF1R inhibitor for triple-negative breast cancer (TNBC) treatment through TAMs reprogramming.

Discovery of novel CSF1R inhibitor for triple-negative breast cancer (TNBC) treatment through TAMs reprogramming.

Journal: Biochemical pharmacology

Published: February 10, 2026

Design and Structural Optimization of Orally Bioavailable RSK4 Inhibitors for the Treatment of Esophageal Squamous Cell Carcinoma.

Design and Structural Optimization of Orally Bioavailable RSK4 Inhibitors for the Treatment of Esophageal Squamous Cell Carcinoma.

Journal: Journal of medicinal chemistry

Published: December 17, 2025

Direct Ser797 Interacted Pteridine-7(8H)-one Derivatives as Highly Selective and Orally Available EGFRL858R/T790M/C797S Inhibitors.

Direct Ser797 Interacted Pteridine-7(8H)-one Derivatives as Highly Selective and Orally Available EGFRL858R/T790M/C797S Inhibitors.

Journal: Journal of medicinal chemistry

Published: August 28, 2025

Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α1-Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents.

Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α1-Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents.

Journal: Journal of medicinal chemistry

Published: August 12, 2025

Exploring the macrocyclic chemical space for heuristic drug design with deep learning models.

Exploring the macrocyclic chemical space for heuristic drug design with deep learning models.

Journal: Communications chemistry

Published: July 14, 2025

Design, Synthesis, and Biological Evaluation of Macrocyclic 2-Amino-4-phenylaminopyrimidine Derivatives as Potent JAK2 Inhibitors.

Design, Synthesis, and Biological Evaluation of Macrocyclic 2-Amino-4-phenylaminopyrimidine Derivatives as Potent JAK2 Inhibitors.

Journal: Journal of medicinal chemistry

Published: June 26, 2025

Inactivation of RhoA for Hypertension Treatment Through the TRPV4-RhoA-RhoGDI1 Axis.

Inactivation of RhoA for Hypertension Treatment Through the TRPV4-RhoA-RhoGDI1 Axis.

Journal: Circulation

Published: June 16, 2025

Discovery of a Proteolysis-Targeting Chimera Degrader of JAK2 as a Potential Therapeutic Agent for JAK2-Mediated Myeloproliferative Neoplasms.

Discovery of a Proteolysis-Targeting Chimera Degrader of JAK2 as a Potential Therapeutic Agent for JAK2-Mediated Myeloproliferative Neoplasms.

Journal: Journal of medicinal chemistry

Published: June 03, 2025

Showing 1-12 of 80

Last Updated: 09/26/2026