Zhichao Chen

Wenzhou, 325001, China

Last Updated: 09/26/2026

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Found 15 publications

Discovery of 6l with a New Skeleton of 6-Oxo-N-(4-(Quinolin-4-yloxy)phenyl)-1,6-dihydropyridine-3-carboxamide as a Dual-Action Inhibitor against JNK2 and the MKK7-JNK2 Protein-Protein Interaction for Acute Lung Injury.

Discovery of 6l with a New Skeleton of 6-Oxo-N-(4-(Quinolin-4-yloxy)phenyl)-1,6-dihydropyridine-3-carboxamide as a Dual-Action Inhibitor against JNK2 and the MKK7-JNK2 Protein-Protein Interaction for Acute Lung Injury.

Journal: Journal of medicinal chemistry

Published: February 23, 2026

Discovery of 3g as an Orally Bioavailable, TIR Domain Selective, and Potent MyD88 Inhibitor for the Treatment of Acute Lung Injury.

Discovery of 3g as an Orally Bioavailable, TIR Domain Selective, and Potent MyD88 Inhibitor for the Treatment of Acute Lung Injury.

Journal: Journal of medicinal chemistry

Published: September 12, 2025

Discovery of c-Kit as a New Therapeutic Target in LPS-Induced Acute Lung Injury through Novel Phenylamide Derivative D9.

Discovery of c-Kit as a New Therapeutic Target in LPS-Induced Acute Lung Injury through Novel Phenylamide Derivative D9.

Journal: Journal of medicinal chemistry

Published: March 24, 2025

Anti-inflammatory agents design via the fragment hybrid strategy in the discovery of compound c1 for treating ALI and UC.

Anti-inflammatory agents design via the fragment hybrid strategy in the discovery of compound c1 for treating ALI and UC.

Journal: European journal of medicinal chemistry

Published: January 18, 2025

A two-strata energy flux system driven by a stress hormone prioritizes cardiac energetics.

A two-strata energy flux system driven by a stress hormone prioritizes cardiac energetics.

Journal: Signal transduction and targeted therapy

Published: January 15, 2025

Enhanced FGF21 Delivery via Neutrophil-Membrane-Coated Nanoparticles Improves Therapeutic Efficacy for Myocardial Ischemia-Reperfusion Injury.

Enhanced FGF21 Delivery via Neutrophil-Membrane-Coated Nanoparticles Improves Therapeutic Efficacy for Myocardial Ischemia-Reperfusion Injury.

Journal: Nanomaterials (Basel, Switzerland)

Published: January 07, 2025

Novel FGF21 analogues through structure-based optimization for therapeutic development.

Novel FGF21 analogues through structure-based optimization for therapeutic development.

Journal: Acta biochimica et biophysica Sinica

Published: December 25, 2024

Discovery of Novel MyD88 Inhibitor A5S to Alleviate Acute Lung Injury with Favorable Drug-like Properties.

Discovery of Novel MyD88 Inhibitor A5S to Alleviate Acute Lung Injury with Favorable Drug-like Properties.

Journal: Journal of medicinal chemistry

Published: December 07, 2024

Strontium-based quaternary ammonium salt chitosan particles for ultrafast hemostasis of open fracture.

Strontium-based quaternary ammonium salt chitosan particles for ultrafast hemostasis of open fracture.

Journal: International journal of biological macromolecules

Published: October 16, 2024

Fragment-Based Anti-inflammatory Agent Design and Target Identification: Discovery of AF-45 as an IRAK4 Inhibitor to Treat Ulcerative Colitis and Acute Lung Injury.

Fragment-Based Anti-inflammatory Agent Design and Target Identification: Discovery of AF-45 as an IRAK4 Inhibitor to Treat Ulcerative Colitis and Acute Lung Injury.

Journal: Journal of medicinal chemistry

Published: June 24, 2024

Discovery of novel osthole derivatives exerting anti-inflammatory effect on DSS-induced ulcerative colitis and LPS-induced acute lung injury in mice.

Discovery of novel osthole derivatives exerting anti-inflammatory effect on DSS-induced ulcerative colitis and LPS-induced acute lung injury in mice.

Journal: European journal of medicinal chemistry

Published: November 29, 2023

Discovery of the Diphenyl 6-Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the JNK2-NF-κB/MAPK Pathway.

Discovery of the Diphenyl 6-Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the JNK2-NF-κB/MAPK Pathway.

Journal: Journal of medicinal chemistry

Published: August 29, 2023

Showing 1-12 of 15

Last Updated: 09/26/2026