Zhifu Xie

State Key Laboratory Of Drug Research
Shanghai, China

Last Updated: 09/26/2026

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Found 11 publications

Discovery of Novel Tridentate Alkenyl Diacid Derivatives as Potent ATP Citrate Lyase Inhibitors for the Treatment of Hepatocellular Carcinoma.

Discovery of Novel Tridentate Alkenyl Diacid Derivatives as Potent ATP Citrate Lyase Inhibitors for the Treatment of Hepatocellular Carcinoma.

Journal: Journal of medicinal chemistry

Published: July 16, 2025

A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics of BGT-002, a Novel ATP-Citrate Lyase Inhibitor, in Healthy Chinese Subjects.

A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics of BGT-002, a Novel ATP-Citrate Lyase Inhibitor, in Healthy Chinese Subjects.

Journal: Drug design, development and therapy

Published: November 06, 2024

A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY.

A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY.

Journal: Theranostics

Published: October 24, 2024

The enedioic acid analog 326E alleviates metabolic dysfunction-associated steatohepatitis via dual targeting at ACLY and PPARα.

The enedioic acid analog 326E alleviates metabolic dysfunction-associated steatohepatitis via dual targeting at ACLY and PPARα.

Journal: Cell metabolism

Published: October 01, 2024

Potential therapeutic strategies for MASH: from preclinical to clinical development.

Potential therapeutic strategies for MASH: from preclinical to clinical development.

Journal: Life metabolism

Published: April 19, 2024

AMPK phosphorylation of FNIP1 (S220) controls mitochondrial function and muscle fuel utilization during exercise.

AMPK phosphorylation of FNIP1 (S220) controls mitochondrial function and muscle fuel utilization during exercise.

Journal: Science advances

Published: February 07, 2024

Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia.

Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia.

Journal: Acta pharmaceutica Sinica. B

Published: February 21, 2022

The triterpenoid sapogenin (2α-OH-Protopanoxadiol) ameliorates metabolic syndrome via the intestinal FXR/GLP-1 axis through gut microbiota remodelling.

The triterpenoid sapogenin (2α-OH-Protopanoxadiol) ameliorates metabolic syndrome via the intestinal FXR/GLP-1 axis through gut microbiota remodelling.

Journal: Cell death & disease

Published: May 23, 2020

Design, synthesis and biological evaluation of mogrol derivatives as a novel class of AMPKα2β1γ1 activators.

Design, synthesis and biological evaluation of mogrol derivatives as a novel class of AMPKα2β1γ1 activators.

Journal: Bioorganic & medicinal chemistry letters

Published: September 17, 2019

Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation.

Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation.

Journal: Diabetes

Published: June 17, 2019

Discovery, synthesis, and structure-activity relationships of 20S-dammar-24-en-2α,3β,12β,20-tetrol (GP) derivatives as a new class of AMPKα2β1γ1 activators.

Discovery, synthesis, and structure-activity relationships of 20S-dammar-24-en-2α,3β,12β,20-tetrol (GP) derivatives as a new class of AMPKα2β1γ1 activators.

Journal: Bioorganic & medicinal chemistry

Published: March 15, 2016

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Last Updated: 09/26/2026