Zhuang G. Yang

Cancer Center And State Key Laboratory Of Biotherapy
Chengdu, 610041, China

Last Updated: 09/26/2026

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Found 58 publications

Design and Synthesis of USP1 Inhibitors: Synergistic Antitumor Activity with PARP Inhibitors in Triple-Negative Breast Cancer.

Design and Synthesis of USP1 Inhibitors: Synergistic Antitumor Activity with PARP Inhibitors in Triple-Negative Breast Cancer.

Journal: Journal of medicinal chemistry

Published: April 29, 2026

Rational Design of Novel pyrazolo[4,3-c]quinoline Derivatives as Potent, Selective, and Orally Bioavailable ATM Inhibitors with Promising In Vivo Efficacy.

Rational Design of Novel pyrazolo[4,3-c]quinoline Derivatives as Potent, Selective, and Orally Bioavailable ATM Inhibitors with Promising In Vivo Efficacy.

Journal: Journal of medicinal chemistry

Published: February 11, 2026

Structure-based design and synthesis of KX-01 analogs as potent antitumor agents targeting the tubulin colchicine binding site.

Structure-based design and synthesis of KX-01 analogs as potent antitumor agents targeting the tubulin colchicine binding site.

Journal: European journal of medicinal chemistry

Published: February 06, 2026

Structure-based design and synthesis of 3-substituted-1,2,4-triazolo[1,5-a]pyrimidines as dual vinca/gatorbulin-site ligands for cancer treatment.

Structure-based design and synthesis of 3-substituted-1,2,4-triazolo[1,5-a]pyrimidines as dual vinca/gatorbulin-site ligands for cancer treatment.

Journal: European journal of medicinal chemistry

Published: August 27, 2025

Discovery and Pharmacological Evaluation of Potent and Highly Selective PARP1 Inhibitors.

Discovery and Pharmacological Evaluation of Potent and Highly Selective PARP1 Inhibitors.

Journal: Journal of medicinal chemistry

Published: June 18, 2025

Design and Synthesis of Novel Deazapurine DNMT 1 Inhibitors with In Vivo Efficacy in DLBCL.

Design and Synthesis of Novel Deazapurine DNMT 1 Inhibitors with In Vivo Efficacy in DLBCL.

Journal: Journal of medicinal chemistry

Published: March 01, 2025

Synthesis of polysubstituted cyclobutanes through a photoredox strain-release/[3,3]-rearrangement cascade.

Synthesis of polysubstituted cyclobutanes through a photoredox strain-release/[3,3]-rearrangement cascade.

Journal: Chemical science

Published: February 22, 2025

Regiodivergent and Enantioselective Allylic C-H Alkylation of Allyl Ethers: Optimization, Scope, Mechanism and Application.

Regiodivergent and Enantioselective Allylic C-H Alkylation of Allyl Ethers: Optimization, Scope, Mechanism and Application.

Journal: Angewandte Chemie (International ed. in English)

Published: January 02, 2025

Correction to: Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2V617F-induced myeloproliferative neoplasms.

Correction to: Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2V617F-induced myeloproliferative neoplasms.

Journal: Blood cancer journal

Published: June 26, 2024

Discovery of Potent and Selective Phosphatidylinositol 3-Phosphate 5-Kinase (PIKfyve) Inhibitors as Methuosis Inducers.

Discovery of Potent and Selective Phosphatidylinositol 3-Phosphate 5-Kinase (PIKfyve) Inhibitors as Methuosis Inducers.

Journal: Journal of medicinal chemistry

Published: December 20, 2023

Discovery, Optimization, and Evaluation of Potent and Selective DNA-PK Inhibitors in Combination with Chemotherapy or Radiotherapy for the Treatment of Malignancies.

Discovery, Optimization, and Evaluation of Potent and Selective DNA-PK Inhibitors in Combination with Chemotherapy or Radiotherapy for the Treatment of Malignancies.

Journal: Journal of medicinal chemistry

Published: December 20, 2023

Therapeutic potential of a synthetic dual JAK1/TYK2 inhibitor in inflammatory bowel disease.

Therapeutic potential of a synthetic dual JAK1/TYK2 inhibitor in inflammatory bowel disease.

Journal: International immunopharmacology

Published: June 18, 2023

Showing 1-12 of 58

Last Updated: 09/26/2026