Zhuang Qian

Xi'an, China

Last Updated: 09/26/2026

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Found 16 publications

Muscone ameliorates osteoarthritis progression by inhibiting M1 macrophages polarization via Nrf2/NF-κB axis and protecting chondrocytes.

Muscone ameliorates osteoarthritis progression by inhibiting M1 macrophages polarization via Nrf2/NF-κB axis and protecting chondrocytes.

Journal: Toxicology and applied pharmacology

Published: June 09, 2025

Sirt1 alleviates osteoarthritis via promoting FoxO1 nucleo-cytoplasm shuttling to facilitate autophagy.

Sirt1 alleviates osteoarthritis via promoting FoxO1 nucleo-cytoplasm shuttling to facilitate autophagy.

Journal: International immunopharmacology

Published: November 09, 2023

Cartilage-specific deficiency of clock gene Bmal1 accelerated articular cartilage degeneration in osteoarthritis by up-regulation of mTORC1 signaling.

Cartilage-specific deficiency of clock gene Bmal1 accelerated articular cartilage degeneration in osteoarthritis by up-regulation of mTORC1 signaling.

Journal: International immunopharmacology

Published: October 26, 2022

Epigenetic regulation of chondrocyte hypertrophy and apoptosis through Sirt1/P53/P21 pathway in surgery-induced osteoarthritis.

Epigenetic regulation of chondrocyte hypertrophy and apoptosis through Sirt1/P53/P21 pathway in surgery-induced osteoarthritis.

Journal: Biochemical and biophysical research communications

Published: March 30, 2020

PGRN exerts inflammatory effects via SIRT1-NF-κB in adipose insulin resistance.

PGRN exerts inflammatory effects via SIRT1-NF-κB in adipose insulin resistance.

Journal: Journal of molecular endocrinology

Published: January 19, 2020

Neuropeptide Y Acts Directly on Cartilage Homeostasis and Exacerbates Progression of Osteoarthritis Through NPY2R.

Neuropeptide Y Acts Directly on Cartilage Homeostasis and Exacerbates Progression of Osteoarthritis Through NPY2R.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Published: September 26, 2019

Postnatal Conditional Deletion of Bmal1 in Osteoblasts Enhances Trabecular Bone Formation Via Increased BMP2 Signals.

Postnatal Conditional Deletion of Bmal1 in Osteoblasts Enhances Trabecular Bone Formation Via Increased BMP2 Signals.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Published: August 14, 2019

Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release.

Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release.

Journal: Cell cycle (Georgetown, Tex.)

Published: July 13, 2019

Cartilage Ablation of Sirt1 Causes Inhibition of Growth Plate Chondrogenesis by Hyperactivation of mTORC1 Signaling.

Cartilage Ablation of Sirt1 Causes Inhibition of Growth Plate Chondrogenesis by Hyperactivation of mTORC1 Signaling.

Journal: Endocrinology

Published: June 08, 2019

Deletion of clock gene Bmal1 impaired the chondrocyte function due to disruption of the HIF1α-VEGF signaling pathway.

Deletion of clock gene Bmal1 impaired the chondrocyte function due to disruption of the HIF1α-VEGF signaling pathway.

Journal: Cell cycle (Georgetown, Tex.)

Published: May 21, 2019

Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss.

Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss.

Journal: Autophagy

Published: July 03, 2018

Addendum to "Cartilage-Specific Autophagy Deficiency Promotes ER Stress and Impairs Chondrogenesis in PERK-ATF4-CHOP-Dependent Manner".

Addendum to "Cartilage-Specific Autophagy Deficiency Promotes ER Stress and Impairs Chondrogenesis in PERK-ATF4-CHOP-Dependent Manner".

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Published: October 14, 2017

Showing 1-12 of 16

Last Updated: 09/26/2026