Ziga Skok

Ljubljana, 1000, Slovenia

Last Updated: 09/26/2026

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Found 22 publications

First dual inhibitors of human topoisomerase IIα and Hsp90 C-terminal domain inhibit the growth of Ewing sarcoma in vitro and in vivo.

First dual inhibitors of human topoisomerase IIα and Hsp90 C-terminal domain inhibit the growth of Ewing sarcoma in vitro and in vivo.

Journal: Bioorganic chemistry

Published: August 01, 2024

New N-phenylpyrrolamide inhibitors of DNA gyrase with improved antibacterial activity.

New N-phenylpyrrolamide inhibitors of DNA gyrase with improved antibacterial activity.

Journal: RSC advances

Published: July 02, 2024

Hiding in plain sight: Optimizing topoisomerase IIα inhibitors into Hsp90β selective binders.

Hiding in plain sight: Optimizing topoisomerase IIα inhibitors into Hsp90β selective binders.

Journal: European journal of medicinal chemistry

Published: May 23, 2024

Improved N-phenylpyrrolamide inhibitors of DNA gyrase as antibacterial agents for high-priority bacterial strains.

Improved N-phenylpyrrolamide inhibitors of DNA gyrase as antibacterial agents for high-priority bacterial strains.

Journal: European journal of medicinal chemistry

Published: April 11, 2024

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus.

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus.

Journal: Journal of medicinal chemistry

Published: March 06, 2023

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa.

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa.

Journal: Journal of medicinal chemistry

Published: January 12, 2023

ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold.

ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold.

Journal: European journal of medicinal chemistry

Published: May 06, 2022

Selective DNA Gyrase Inhibitors: Multi-Target in Silico Profiling with 3D-Pharmacophores.

Selective DNA Gyrase Inhibitors: Multi-Target in Silico Profiling with 3D-Pharmacophores.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: July 02, 2021

Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation.

Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation.

Journal: Pharmaceutics

Published: November 30, 2020

New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens.

New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens.

Journal: European journal of medicinal chemistry

Published: October 06, 2020

Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors.

Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors.

Journal: ACS medicinal chemistry letters

Published: July 29, 2020

Discovery of new ATP-competitive inhibitors of human DNA topoisomerase IIα through screening of bacterial topoisomerase inhibitors.

Discovery of new ATP-competitive inhibitors of human DNA topoisomerase IIα through screening of bacterial topoisomerase inhibitors.

Journal: Bioorganic chemistry

Published: April 12, 2020

Showing 1-12 of 22

Last Updated: 09/26/2026