Ziqi Huang

The State Key Laboratory Of Medicinal Chemical Biology
Changhongjie, 300071, China

Last Updated: 09/26/2026

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Found 11 publications

Discovery of a Selective DNMT1 Degrader with a Unique Molecular Glue Mechanism as a Potential Therapeutic Agent for Acute Myeloid Leukemia.

Discovery of a Selective DNMT1 Degrader with a Unique Molecular Glue Mechanism as a Potential Therapeutic Agent for Acute Myeloid Leukemia.

Journal: Journal of medicinal chemistry

Published: March 24, 2026

Structural optimization of AR and AR-V7 degraders incorporating silicon-based hydrophobic tags for treatment of castration-resistant prostate cancer.

Structural optimization of AR and AR-V7 degraders incorporating silicon-based hydrophobic tags for treatment of castration-resistant prostate cancer.

Journal: European journal of medicinal chemistry

Published: December 02, 2025

Translational Research on the Oral Delivery of the Cytotoxic PROTAC Molecule via Tumor-Targeting Prodrug Strategy for Triple-Negative Breast Cancer Treatment.

Translational Research on the Oral Delivery of the Cytotoxic PROTAC Molecule via Tumor-Targeting Prodrug Strategy for Triple-Negative Breast Cancer Treatment.

Journal: Journal of medicinal chemistry

Published: September 22, 2025

Low expression of ONECUT2 governs the POU6F2-beta-catenin axis to modulate cancer stemness and drives the CCL28-dependent pathway for macrophage polarization in breast cancer.

Low expression of ONECUT2 governs the POU6F2-beta-catenin axis to modulate cancer stemness and drives the CCL28-dependent pathway for macrophage polarization in breast cancer.

Journal: Cell death & disease

Published: September 02, 2025

Lactate metabolism and epigenetic reprogramming drive c-KIT hyperactivation to mediate Gilteritinib resistance: Rationale for c-KIT degraders over kinase inhibitors.

Lactate metabolism and epigenetic reprogramming drive c-KIT hyperactivation to mediate Gilteritinib resistance: Rationale for c-KIT degraders over kinase inhibitors.

Journal: Acta pharmaceutica Sinica. B

Published: August 05, 2025

Development of Novel Silicon-Based Hydrophobic Tags (SiHyT) for Targeted Proteins Degradation.

Development of Novel Silicon-Based Hydrophobic Tags (SiHyT) for Targeted Proteins Degradation.

Journal: Journal of medicinal chemistry

Published: December 02, 2024

Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH.

Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH.

Journal: Acta pharmaceutica Sinica. B

Published: February 06, 2024

Cobalt loaded electrospun poly(ε-caprolactone) grafts promote antibacterial activity and vascular regeneration in a diabetic rat model.

Cobalt loaded electrospun poly(ε-caprolactone) grafts promote antibacterial activity and vascular regeneration in a diabetic rat model.

Journal: Biomaterials

Published: June 21, 2021

Aligned microfiber-induced macrophage polarization to guide schwann-cell-enabled peripheral nerve regeneration.

Aligned microfiber-induced macrophage polarization to guide schwann-cell-enabled peripheral nerve regeneration.

Journal: Biomaterials

Published: December 08, 2020

The effect of hypoxia-mimicking responses on improving the regeneration of artificial vascular grafts.

The effect of hypoxia-mimicking responses on improving the regeneration of artificial vascular grafts.

Journal: Biomaterials

Published: October 07, 2020

Cobalt-mediated multi-functional dressings promote bacteria-infected wound healing.

Cobalt-mediated multi-functional dressings promote bacteria-infected wound healing.

Journal: Acta biomaterialia

Published: September 11, 2018

Showing 1-11 of 11

Last Updated: 09/26/2026