Zofia Chrienova

Hradec Kralove, KR 50003, Czech Republic

Last Updated: 09/26/2026

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Found 17 publications

The structure-activity relationship study of torkinib derivatives as mTOR inhibitors with senolytic and STAT3 inhibitory activities.

The structure-activity relationship study of torkinib derivatives as mTOR inhibitors with senolytic and STAT3 inhibitory activities.

Journal: Bioorganic chemistry

Published: January 14, 2026

In silico screening, synthesis, and biological evaluation of pyrazolopyrimidine-derived mTOR inhibitors for anticancer and senomorphic effects.

In silico screening, synthesis, and biological evaluation of pyrazolopyrimidine-derived mTOR inhibitors for anticancer and senomorphic effects.

Journal: Cancer cell international

Published: September 05, 2025

Erratum to "Frentizole derivatives with mTOR inhibiting and senomorphic properties" [Biomed. Pharmacother. 167 (2023) 115600].

Erratum to "Frentizole derivatives with mTOR inhibiting and senomorphic properties" [Biomed. Pharmacother. 167 (2023) 115600].

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: February 09, 2025

Targeted Inhibition of the PI3K/Akt/mTOR Signaling Axis: Potential for Sarcoma Therapy.

Targeted Inhibition of the PI3K/Akt/mTOR Signaling Axis: Potential for Sarcoma Therapy.

Journal: Mini reviews in medicinal chemistry

Published: July 06, 2023

Frentizole derivatives with mTOR inhibiting and senomorphic properties.

Frentizole derivatives with mTOR inhibiting and senomorphic properties.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: July 04, 2023

The role of redox active copper(II) on antioxidant properties of the flavonoid baicalein: DNA protection under Cu(II)-Fenton reaction and Cu(II)-ascorbate system conditions.

The role of redox active copper(II) on antioxidant properties of the flavonoid baicalein: DNA protection under Cu(II)-Fenton reaction and Cu(II)-ascorbate system conditions.

Journal: Journal of inorganic biochemistry

Published: March 11, 2023

Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities.

Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities.

Journal: Journal of enzyme inhibition and medicinal chemistry

Published: September 22, 2022

Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics.

Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics.

Journal: Frontiers in aging neuroscience

Published: September 19, 2022

Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015-2021).

Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015-2021).

Journal: European journal of medicinal chemistry

Published: March 27, 2022

Phytoremediation of heavy metal pollution: Hotspots and future prospects.

Phytoremediation of heavy metal pollution: Hotspots and future prospects.

Journal: Ecotoxicology and environmental safety

Published: September 15, 2021

The role of mTOR in age-related diseases.

The role of mTOR in age-related diseases.

Journal: Journal of enzyme inhibition and medicinal chemistry

Published: July 26, 2021

Hypoxia, oxidative stress, and immune evasion: a trinity of the trichothecenes T-2 toxin and deoxynivalenol (DON).

Hypoxia, oxidative stress, and immune evasion: a trinity of the trichothecenes T-2 toxin and deoxynivalenol (DON).

Journal: Archives of toxicology

Published: February 08, 2021

Showing 1-12 of 17

Last Updated: 09/26/2026