Zunsheng Han

State Key Laboratory Of Bioactive Substance And Function Of Natural Medicines, Chinese Academy Of Medical Sciences & Peking Union Medical College
Beijing, 100050, China

Last Updated: 09/26/2026

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Found 12 publications

Development and Evaluation of a Phospholipid Complex-Loaded SMEDDS for Enhanced Oral Delivery of H007, a Novel Anti-Hyperlipidemic Drug.

Development and Evaluation of a Phospholipid Complex-Loaded SMEDDS for Enhanced Oral Delivery of H007, a Novel Anti-Hyperlipidemic Drug.

Journal: Pharmaceutics

Published: March 05, 2026

4-Hydroxy-2,5-dihydrothiazole derivatives as a new class of small-molecule antibiotics for MRSA: AI-integrated design, chemical synthesis and biological evaluation.

4-Hydroxy-2,5-dihydrothiazole derivatives as a new class of small-molecule antibiotics for MRSA: AI-integrated design, chemical synthesis and biological evaluation.

Journal: European journal of medicinal chemistry

Published: August 06, 2025

Discovery of novel 1,4-dicarbonylthiosemicarbazides as DNA gyrase inhibitors for the treatment of MRSA infection.

Discovery of novel 1,4-dicarbonylthiosemicarbazides as DNA gyrase inhibitors for the treatment of MRSA infection.

Journal: European journal of medicinal chemistry

Published: August 24, 2024

The state-of-the-art machine learning model for plasma protein binding prediction: Computational modeling with OCHEM and experimental validation.

The state-of-the-art machine learning model for plasma protein binding prediction: Computational modeling with OCHEM and experimental validation.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: July 30, 2024

Novel pleuromutilin derivatives conjugated with phenyl-sulfide and boron-containing moieties as potent antibacterial agents against antibiotic-resistant bacteria.

Novel pleuromutilin derivatives conjugated with phenyl-sulfide and boron-containing moieties as potent antibacterial agents against antibiotic-resistant bacteria.

Journal: European journal of medicinal chemistry

Published: May 25, 2024

Discovery of Oral AMP-Activated Protein Kinase Activators for Treating Hyperlipidemia.

Discovery of Oral AMP-Activated Protein Kinase Activators for Treating Hyperlipidemia.

Journal: Journal of medicinal chemistry

Published: May 13, 2024

AutoMolDesigner for Antibiotic Discovery: An AI-Based Open-Source Software for Automated Design of Small-Molecule Antibiotics.

AutoMolDesigner for Antibiotic Discovery: An AI-Based Open-Source Software for Automated Design of Small-Molecule Antibiotics.

Journal: Journal of chemical information and modeling

Published: January 24, 2024

Exploration and Biological Evaluation of 1,3-Diamino-7H-pyrrol[3,2-f]quinazoline Derivatives as Dihydrofolate Reductase Inhibitors.

Exploration and Biological Evaluation of 1,3-Diamino-7H-pyrrol[3,2-f]quinazoline Derivatives as Dihydrofolate Reductase Inhibitors.

Journal: Journal of medicinal chemistry

Published: September 12, 2023

Development and In Vitro-In Vivo Correlation Evaluation of IMM-H014 Extended-Release Tablets for the Treatment of Fatty Liver Disease.

Development and In Vitro-In Vivo Correlation Evaluation of IMM-H014 Extended-Release Tablets for the Treatment of Fatty Liver Disease.

Journal: International journal of molecular sciences

Published: July 05, 2023

Discovery of isatin-β-methyldithiocarbazate derivatives as New Delhi metallo- β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates.

Discovery of isatin-β-methyldithiocarbazate derivatives as New Delhi metallo- β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: June 23, 2023

Discovery and druggability evaluation of pyrrolamide-type GyrB/ParE inhibitor against drug-resistant bacterial infection.

Discovery and druggability evaluation of pyrrolamide-type GyrB/ParE inhibitor against drug-resistant bacterial infection.

Journal: Acta pharmaceutica Sinica. B

Published: March 29, 2023

Discovery of N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents.

Discovery of N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents.

Journal: Journal of enzyme inhibition and medicinal chemistry

Published: October 24, 2022

Showing 1-12 of 12

Last Updated: 09/26/2026