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          Last Updated: 10/31/2025

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          2 clinical trials found

            Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for OligoRecurrenT Prostate Cancer (VA STARPORT)

            Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for OligoRecurrenT Prostate Cancer (VA STARPORT)

            Who is this study for: Patients with Prostate Cancer
            Enrollment Status: Recruiting
            Publish Date: October 14, 2025
            Intervention Type: Drug, Procedure, Radiation, Other
            Study Drugs: Goserelin, Histrelin, Leuprolide & Triptorelin, Androgen Deprivation Therapy + Nilutamide, Flutamide, & Bicalutamide, Degarelix, Androgen Deprivation Therapy + Docetaxel +/- Prednisone, Androgen Deprivation Therapy + Abiraterone + Prednisone, Androgen Deprivation Therapy + Abiraterone + Methylprednisolone, Androgen Deprivation Therapy + Apalutamide, Androgen Deprivation Therapy + Enzalutamide
            Study Phase: Phase 2/Phase 3

            Summary: This is a prospective, open-label, multi-center seamless phase II to phase III randomized clinical trial designed to compare SST with or without PET-directed local therapy in improving the castration-resistant prostate cancer-free survival (CRPC-free survival) for Veterans with oligometastatic prostate cancer. Oligometastasis will be defined as 1-10 sites of metastatic disease based on the clinica...

            Phase III Randomized Trial of Standard Systemic Therapy (SST) Versus Standard Systemic Therapy Plus Definitive Treatment (Surgery or Radiation) of the Primary Tumor in Metastatic Prostate Cancer

            Phase III Randomized Trial of Standard Systemic Therapy (SST) Versus Standard Systemic Therapy Plus Definitive Treatment (Surgery or Radiation) of the Primary Tumor in Metastatic Prostate Cancer

            Who is this study for: Adult patients with metastatic castration-resistant prostate cancer
            Enrollment Status: Recruiting
            Publish Date: September 11, 2025
            Intervention Type: Procedure, Drug, Other, Radiation
            Study Drugs: Abiraterone, Bicalutamide, Degarelix, Docetaxel, Flutamide, Goserelin acetate, Histrelin acetate, Leuprolide acetate, Nilutamide, Prednisone, Triptorelin
            Study Phase: Phase 3

            Summary: This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Addition of prostate removal surgery or radiation therapy to standard systemic therapy for prostate cancer may lower the chance of the cancer growing or s...

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            Last Updated: 10/31/2025