Mexiletine - Latest Advances

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

Published: September 15, 2025

The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Nav1.5 channels.

Journal: American journal of physiology. Heart and circulatory physiology

Published: August 12, 2025

Mutation-specific roles of sustained sodium current (INa) in guiding precision medicine for long QT syndrome type 3.

Journal: PNAS nexus

Published: August 07, 2025

Integrating drug effects on individual cardiac ionic currents and cardiac action potentials to understand nonclinical translation to clinical ECG changes.

Journal: Frontiers in pharmacology

Published: August 05, 2025

Shenlian-Fumai formula attenuates ventricular arrhythmias via modulating sodium channel function in heart failure mice.

Journal: Journal of ethnopharmacology

Published: July 31, 2025

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ECG artefact or life-threatening arrhythmia? A neonatal presentation of Long QT syndrome type 3 with a de novo SCN5A mutation.

ECG artefact or life-threatening arrhythmia? A neonatal presentation of Long QT syndrome type 3 with a de novo SCN5A mutation.

Stability assessment of a novel 3D-printed oral dosage form of Mexiletine Hydrochloride: a six-month shelf-life study.

Stability assessment of a novel 3D-printed oral dosage form of Mexiletine Hydrochloride: a six-month shelf-life study.

Reductant-Controlled Access to Sulfinamides from Aliphatic Primary Amines.

Reductant-Controlled Access to Sulfinamides from Aliphatic Primary Amines.

Repositioning lidocaine as a TMEM16A Ca2+-activated Cl- channel blocker for the treatment of pulmonary arterial hypertension.

Repositioning lidocaine as a TMEM16A Ca2+-activated Cl- channel blocker for the treatment of pulmonary arterial hypertension.

Advanced Cardiotoxicity Profiling Using Field Potential Imaging with UHD-CMOS-MEA in Human iPSC-Derived Cardiomyocytes.

Advanced Cardiotoxicity Profiling Using Field Potential Imaging with UHD-CMOS-MEA in Human iPSC-Derived Cardiomyocytes.

Mexiletine as Adjunctive Therapy in Atrial Fibrillation Following Dofetilide Treatment Failure.

Mexiletine as Adjunctive Therapy in Atrial Fibrillation Following Dofetilide Treatment Failure.

Long-Term Outcomes and Post-Ablation Medication De-Escalation After Catheter Ablation for Premature Ventricular Complexes: A Nationwide Cohort Study.

Long-Term Outcomes and Post-Ablation Medication De-Escalation After Catheter Ablation for Premature Ventricular Complexes: A Nationwide Cohort Study.

Implantable Cardioverter Defibrillators for Long QT syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia? (Not so fast, Louis).

Implantable Cardioverter Defibrillators for Long QT syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia? (Not so fast, Louis).

The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Nav1.5 channels.

The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Nav1.5 channels.

Mutation-specific roles of sustained sodium current (INa) in guiding precision medicine for long QT syndrome type 3.

Mutation-specific roles of sustained sodium current (INa) in guiding precision medicine for long QT syndrome type 3.

Integrating drug effects on individual cardiac ionic currents and cardiac action potentials to understand nonclinical translation to clinical ECG changes.

Integrating drug effects on individual cardiac ionic currents and cardiac action potentials to understand nonclinical translation to clinical ECG changes.

Shenlian-Fumai formula attenuates ventricular arrhythmias via modulating sodium channel function in heart failure mice.

Shenlian-Fumai formula attenuates ventricular arrhythmias via modulating sodium channel function in heart failure mice.