Summary: This study is designed to demonstrate the efficacy and assess safety and tolerability of oral daily alpelisib in participants with PIK3CA-related overgrowth spectrum (PROS).

Summary: The goal of this study is to test a potentially easier method for measuring how much insulin a person is capable of producing than the current gold-standard method, the hyperglycemic clamp. Participants will come in for a two-day (overnight) visit in which they will first undergo a hyperglycemic clamp, in which they receive an intravenous (into the vein) infusion of glucose (sugar) in order to mea...

Summary: This ComboMATCH patient screening trial is the gateway to a coordinated set of clinical trials to study cancer treatment directed by genetic testing. Patients with solid tumors that have spread to nearby tissue or lymph nodes (locally advanced) or have spread to other places in the body (advanced) and have progressed on at least one line of standard systemic therapy or have no standard treatment t...