Pitolisant

Last Updated: 04/28/2026

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Found 231 publications

Therapeutic potential of histamine N-methyltransferase inhibition for the treatment of hypersomnia

Therapeutic potential of histamine N-methyltransferase inhibition for the treatment of hypersomnia

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Published: March 01, 2026

Samelisant (SUVN-G3031), a histamine H3 receptor inverse agonist, as a potential treatment for narcolepsy: a phase-2 Drug evaluation.

Samelisant (SUVN-G3031), a histamine H3 receptor inverse agonist, as a potential treatment for narcolepsy: a phase-2 Drug evaluation.

Journal: Expert opinion on investigational drugs
Published: February 23, 2026

Rational Design, Synthesis and Pharmacological Evaluation of Chalcones as Dual-Acting Compounds-Histamine H3 Receptor Ligands and MAO-B Inhibitors.

Rational Design, Synthesis and Pharmacological Evaluation of Chalcones as Dual-Acting Compounds-Histamine H3 Receptor Ligands and MAO-B Inhibitors.

Journal: International journal of molecular sciences
Published: December 05, 2025

Pitolisant-associated mania - a case report.

Pitolisant-associated mania - a case report.

Journal: BMC neurology
Published: December 01, 2025

Efficacy and Safety of Pitolisant for Excessive Daytime Sleepiness in Narcolepsy and Obstructive Sleep Apnea: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Efficacy and Safety of Pitolisant for Excessive Daytime Sleepiness in Narcolepsy and Obstructive Sleep Apnea: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Journal: The Annals of pharmacotherapy
Published: December 01, 2025

Antiseizure Medications that Did Not Reach the Epilepsy Market: An Assessment of Factors Contributing to Their Failed Clinical Development Over the Last Three Decades.

Antiseizure Medications that Did Not Reach the Epilepsy Market: An Assessment of Factors Contributing to Their Failed Clinical Development Over the Last Three Decades.

Journal: Drugs
Published: November 26, 2025

Reciprocal regulation of the H3 histamine receptor in Rett syndrome and MECP2 Duplication syndrome: implications for therapeutic development.

Reciprocal regulation of the H3 histamine receptor in Rett syndrome and MECP2 Duplication syndrome: implications for therapeutic development.

Journal: bioRxiv : the preprint server for biology
Published: November 24, 2025

A real-world study on the treatment of pediatric narcolepsy with pitolisant in China.

A real-world study on the treatment of pediatric narcolepsy with pitolisant in China.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Published: November 03, 2025

Pharmacological modulation of wakefulness and extracellular hypothalamic histamine release in adult male mice using TAK-925, modafinil, pitolisant, MK-8133 and Lu AF11167.

Pharmacological modulation of wakefulness and extracellular hypothalamic histamine release in adult male mice using TAK-925, modafinil, pitolisant, MK-8133 and Lu AF11167.

Journal: Neuropharmacology
Published: October 15, 2025

Drug Interactions With Excessive Daytime Sleepiness Treatments.

Drug Interactions With Excessive Daytime Sleepiness Treatments.

Journal: The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians
Published: October 07, 2025

Understanding idiopathic hypersomnia: diagnosis, pathophysiology, and management.

Understanding idiopathic hypersomnia: diagnosis, pathophysiology, and management.

Journal: Current opinion in pulmonary medicine
Published: September 24, 2025

Pitolisant may lessen not only sleepiness but improve hyperphagia and behavior problems in Prader-Willi syndrome.

Pitolisant may lessen not only sleepiness but improve hyperphagia and behavior problems in Prader-Willi syndrome.

Journal: Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Published: September 12, 2025
Showing 1-12 of 231

Last Updated: 04/28/2026