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Last Updated: 10/31/2025
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2 clinical trials found
A Phase I Study of Nelfinavir and Cisplatin Chemotherapy Concurrent With Pelvic Radiation for Locally Advanced Vulvar Cancer Not Amenable to Surgical Resection
Who is this study for: Patients with Vulvar Cancer
Enrollment Status: Recruiting
Publish Date: October 14, 2025
Intervention Type: Drug, Radiation
Study Drugs: Cisplatin, Nelfinavir
Study Phase: Phase 1
Summary: This phase I trial studies the side effects and best dose of nelfinavir when given together with cisplatin and external beam radiation therapy in treating patients with vulvar cancer that has spread to nearby tissue or lymph nodes (locally advanced) and cannot be removed by surgery. Nelfinavir is an antiviral drug normally used to treat human immunodeficiency virus (HIV). Drugs used in chemotherap...
Combination of Autophagy Selective Therapeutics (COAST) in Advanced Solid Tumors or Relapsed Prostate Cancer, A Phase I/II Trial
Who is this study for: Patients with Solid Tumors
Enrollment Status: Recruiting
Publish Date: October 06, 2025
Intervention Type: Combination product
Study Drugs: Hydroxychloroquine+Metformin+Sirolimus, Hydroxychloroquine+Metformin+Sirolimus+Dasatanib, Hydroxychloroquine+Metformin+Sirolimus+Nelfinavir, Hydroxychloroquine+Metformin+Sirolimus+Nelfinavir+Dasatinib
Study Phase: Phase 1/Phase 2
Summary: The purpose of this Phase I/II study is to determine the safety and effectiveness of up to 5 study drugs used together for the treatment of solid tumor cancers. The drugs are hydroxychloroquine, metformin, sirolimus, dasatinib and nelfinavir and are given orally.
Showing 1-2 of 2
Last Updated: 10/31/2025