Eflornithine - Latest Advances

STELLAR: Phase III, Randomized, Open-Label Study of Eflornithine Plus Lomustine Versus Lomustine Alone in Patients With Recurrent Grade 3 Astrocytoma.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Published: December 01, 2025

Combination of Intense Pulsed Light and Topical Eflornithine Therapy Versus Intense Pulsed Light Alone in the Treatment of Idiopathic Facial Hirsutism: A Randomized Controlled Trial.

Journal: Cureus

Published: August 18, 2025

Human African Trypanosomiasis (HAT): Epidemiology, Biological Diagnosis and Treatment: A Review.

Journal: Acta parasitologica

Published: June 28, 2025

Polyamines regulate mitochondrial metabolism essential for intestinal epithelial renewal and wound healing.

Journal: American journal of physiology. Gastrointestinal and liver physiology

Published: June 05, 2025

Spermine suppresses GBP5-mediated NLRP3 inflammasome activation in macrophages to relieve vital organ injuries in neonatal mice with enterovirus 71 infection

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University

Published: May 26, 2025

Preclinical Evaluation of the Efficacy of α-Difluoromethylornithine and Sulindac Against SARS-CoV-2 Infection.

Journal: Viruses

Published: May 19, 2025

Polyamine transport inhibitors: Methods and caveats associated with measuring polyamine uptake in mammalian cells.

Journal: Methods in enzymology

Published: May 17, 2025

Novel LC-MS/MS assay to quantify D,L-alpha-difluoromethylornithine (DFMO) in mouse plasma.

Journal: Methods in enzymology

Published: May 17, 2025

Pharmacokinetics of Racemic Eflornithine in Human Plasma and Cerebrospinal Fluid: Clinical Perspectives for L-eflornithine Against Human African Trypanosomiasis.

Journal: The AAPS journal

Published: May 05, 2025

Use of fexinidazole in gambiense human African trypanosomiasis: a retrospective analysis of cases treated in Lui Hospital, South Sudan (2018-2024).

Journal: Infection

Published: April 15, 2025

Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer.

Journal: Cancer research

Published: April 07, 2025

Phase I dose-escalation trial of AMXT 1501 dicaprate plus difluoromethylornithine: a dual-agent approach targeting immunosuppressive polyamine metabolism.

Journal: ESMO open

Published: April 04, 2025

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STELLAR: Phase III, Randomized, Open-Label Study of Eflornithine Plus Lomustine Versus Lomustine Alone in Patients With Recurrent Grade 3 Astrocytoma.

STELLAR: Phase III, Randomized, Open-Label Study of Eflornithine Plus Lomustine Versus Lomustine Alone in Patients With Recurrent Grade 3 Astrocytoma.

Combination of Intense Pulsed Light and Topical Eflornithine Therapy Versus Intense Pulsed Light Alone in the Treatment of Idiopathic Facial Hirsutism: A Randomized Controlled Trial.

Combination of Intense Pulsed Light and Topical Eflornithine Therapy Versus Intense Pulsed Light Alone in the Treatment of Idiopathic Facial Hirsutism: A Randomized Controlled Trial.

Human African Trypanosomiasis (HAT): Epidemiology, Biological Diagnosis and Treatment: A Review.

Human African Trypanosomiasis (HAT): Epidemiology, Biological Diagnosis and Treatment: A Review.

Polyamines regulate mitochondrial metabolism essential for intestinal epithelial renewal and wound healing.

Polyamines regulate mitochondrial metabolism essential for intestinal epithelial renewal and wound healing.

Spermine suppresses GBP5-mediated NLRP3 inflammasome activation in macrophages to relieve vital organ injuries in neonatal mice with enterovirus 71 infection

Spermine suppresses GBP5-mediated NLRP3 inflammasome activation in macrophages to relieve vital organ injuries in neonatal mice with enterovirus 71 infection

Preclinical Evaluation of the Efficacy of α-Difluoromethylornithine and Sulindac Against SARS-CoV-2 Infection.

Preclinical Evaluation of the Efficacy of α-Difluoromethylornithine and Sulindac Against SARS-CoV-2 Infection.

Polyamine transport inhibitors: Methods and caveats associated with measuring polyamine uptake in mammalian cells.

Polyamine transport inhibitors: Methods and caveats associated with measuring polyamine uptake in mammalian cells.

Novel LC-MS/MS assay to quantify D,L-alpha-difluoromethylornithine (DFMO) in mouse plasma.

Novel LC-MS/MS assay to quantify D,L-alpha-difluoromethylornithine (DFMO) in mouse plasma.

Pharmacokinetics of Racemic Eflornithine in Human Plasma and Cerebrospinal Fluid: Clinical Perspectives for L-eflornithine Against Human African Trypanosomiasis.

Pharmacokinetics of Racemic Eflornithine in Human Plasma and Cerebrospinal Fluid: Clinical Perspectives for L-eflornithine Against Human African Trypanosomiasis.

Use of fexinidazole in gambiense human African trypanosomiasis: a retrospective analysis of cases treated in Lui Hospital, South Sudan (2018-2024).

Use of fexinidazole in gambiense human African trypanosomiasis: a retrospective analysis of cases treated in Lui Hospital, South Sudan (2018-2024).

Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer.

Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer.

Phase I dose-escalation trial of AMXT 1501 dicaprate plus difluoromethylornithine: a dual-agent approach targeting immunosuppressive polyamine metabolism.

Phase I dose-escalation trial of AMXT 1501 dicaprate plus difluoromethylornithine: a dual-agent approach targeting immunosuppressive polyamine metabolism.