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          Last Updated: 01/07/2026

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          2 clinical trials found

            Randomized Double-Blind Placebo-Controlled Phase 3 Study to Evaluate the Efficacy and Safety of Maralixibat in the Treatment of Participants With Cholestatic Pruritus

            Randomized Double-Blind Placebo-Controlled Phase 3 Study to Evaluate the Efficacy and Safety of Maralixibat in the Treatment of Participants With Cholestatic Pruritus

            Enrollment Status: Recruiting
            Publish Date: December 11, 2025
            Intervention Type: Other, Drug
            Study Phase: Phase 3

            Summary: The purpose of this study is to determine whether the investigational treatment (maralixibat) is safe and effective in pediatric and adult participants who have cholestatic liver disease with pruritus that has been refractory to other therapies, and who have no other treatment options.

            Long-Term SafEty and Clinical Outcomes of LivmArli in Patients in the United States (LEAP-US)

            Long-Term SafEty and Clinical Outcomes of LivmArli in Patients in the United States (LEAP-US)

            Enrollment Status: Recruiting
            Publish Date: May 25, 2025
            Intervention Type: Drug

            Summary: The objective of this 5-year, prospective, observational cohort study is to evaluate the long-term safety and clinical outcomes of patients with Alagille syndrome (ALGS) or Progressive familial intrahepatic cholestasis (PFIC) treated with Livmarli.

            Showing 1-2 of 2

            Last Updated: 01/07/2026