Colesevelam
Last Updated: 04/28/2026
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2 clinical trials found
Assessing the Impact of a Bile Acid Sequestrant on Serum PFAS Levels in Highly Exposed Individuals
Enrollment Status: Recruiting
Publish Date: March 06, 2026
Intervention Type: Drug
Study Phase: Phase 1/Phase 2
Summary: This randomized, placebo-controlled crossover trial will test the feasibility and acceptability of using colesevelam in male firefighters with high per- and polyfluoroalkyl substances (PFAS) exposure. This trial will also explore whether colesevelam lowers blood PFAS levels and urine environmental toxicant and mold mycotoxin levels.
Metabolic Effects of Endogenous Bile Acids After Gastric Bypass Surgery
Enrollment Status: Recruiting
Publish Date: April 13, 2025
Intervention Type: Drug
Study Phase: Early Phase 1
Summary: Non-randomized, open-label, parallel-group clinical study evaluating the effects of endogenous bile acids on changes in plasma fibroblast growth factor-19 (FGF-19) and glucose metabolism by extended depletion of circulating bile acids using colesevelam as an experimental tool in subjects operated with gastric by-pass (RYGB).
Showing 1-2 of 2
Last Updated: 04/28/2026