Microbiome and Association With Implant Infections: Investigating the Impact of Antibiotics on the Gut and Breast Microbiomes Post-mastectomy With Implant-based Breast Reconstruction
The most common tissue expander-related infections are from Staphylococcus and Pseudomonas species. In addition, from breast tissue microbiome studies, Staphylococcus and Pseudomonas show variable abundance across samples. The investigator hypothesizes that participants undergoing mastectomy with high initial abundance of Staphylococcus and/or Pseudomonas are more likely to develop subsequent tissue expander-related infections from these respective organisms.
• Patients must have histologically confirmed breast malignancy OR genetic predisposition to breast cancer.
• Age \>= 18 years
• Scheduled to undergo mastectomy with the immediate placement of tissue expanders or implant placement
• Ability to understand a written informed consent document, and the willingness to sign it
• At least 4 weeks post-completion of chemotherapy or radiation therapy.