High Dose Dexamethasone In High-Pain Responders Undergoing Enhanced Recovery Video-Assisted Thoracoscopic Surgery Lobectomy and Segmentectomy - A Randomized Double-Blinded Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY
The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg/kg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to High-pain-responders in patients undergoing VATS lobectomy/segmentectomy. The hypothesis is that a high dose of Dexamethasone can lower pain when coughing in the morning after VATS lobectomy/segmentectomy, in patients scoring as High-pain-responders on the Pain-Catastrophizing-Scale
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Age ≥ 18 year
• Able to understand written and spoken Danish language
• PCS ≥20
• Signed written informed consent form.
• Patient planned to elective VATS lobectomy/segmentectomy
Locations
Other Locations
Denmark
Department for Cardiothoracic Surgery, Rigshospitalet
RECRUITING
Copenhagen
Contact Information
Primary
Lasse Visby, Medical Doctor
lasse.visby@regionh.dk
+4522246982
Time Frame
Start Date: 2025-09-01
Estimated Completion Date: 2026-11
Participants
Target number of participants: 80
Treatments
Active_comparator: Low dose Dexamethasone (8mg)
Active_comparator: High dose Dexamethasone (1mg/kg)
Related Therapeutic Areas
Sponsors
Leads: Rigshospitalet, Denmark