Hypofractionated Versus Conventional Fractionated Radiotherapy After Breast Conserving Surgery：a Multi-center Phase III Randomized Clinical Trial
The study was designed to investigate whether hypofractionated radiotherapy(HF-RT) is noninferior to conventionally fractionated radiotherapy (CF-RT) in terms of tumor loco-regional control for patients after breast conserving surgery
• Female
• Age18-70 years
• Imaging examination confirmed single lesion. if the tumor is multiple, it needs to be removed by single quadrantectomy
• Receive breast conserving surgery with negative margins
• Axillary lymph nodes treatment: Sentinel lymph node biopsy or level I/II axillary lymph node dissection. If the sentinel lymph node is negative, the axillary lymph node dissection can be omitted. If it is positive, level I/II axillary lymph node dissection with or more than 10 lymph nodes is needed.
• The tumor bed is labeled with clips and it can be drawn on the treatment planning system.
• Pathologically confirmed invasive breast cancer
• Pathologically stage is T1-3N0-3M0
• Immunohistochemical examination is conducted to determine the status of ER, PR, HER2, Ki67 after surgery
• No distant metastases
• No supraclavicular or internal mammary nodes metastases
• No neoadjuvant chemotherapy
• Fit for postoperative radiotherapy. No contraindications to radiotherapy
• KPS≥80
• Signed informed consent