Improving Endometrial Cancer Assessment by Combining the New techniqUe of GENomic Profiling With Surgical Extra uterIne disEase Assessment

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

EUGENIE is a prospective multicentre interventional study, focused on improving endometrial cancer (EC) assessment by combining the new technique of genomic profiling with surgical extra uterine disease assessment. The investigators aim to correlate EC stage to each of the molecular subgroups of disease and thereby guide surgical treatment and staging of EC by determining the association between molecular classification and disease stage and evaluating if and how disease stage in each of the molecular subgroups associates with prognosis.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:

• Voluntary written informed consent of the participant or their legally authorized representative has been obtained before any screening procedures

• Women ≥ 18 years

• First diagnosis of EC, all disease stages and all histo-types

Locations
Other Locations
Belgium
UZ Gasthuisberg, Katholieke Universiteit Leuven
RECRUITING
Leuven
Contact Information
Primary
Frédéric Amant, MD, PhD
frederic.amant@uzleuven.be
+3216342194
Backup
Ayaka Wakatsuki, Msc
ayaka.wakatsuki@uzleuven.be
+3216344169
Time Frame
Start Date: 2023-01-16
Estimated Completion Date: 2028-11-01
Participants
Target number of participants: 1000
Treatments
Experimental: All women older than 18 newly diagnosed with endometrial cancer of all stages and histotypes
All patients must undergo total hysterectomy and bilateral salpingo-oophorectomy or bilateral salpingectomy if premenopausal status and the lymph-node assessment according to European guidelines and local protocol. A comprehensive surgical peritoneal staging is required, which includes omentectomy/omental biopsies and six peritoneal biopsies.
Sponsors
Collaborators: University Medical Centre Maribor, Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Leads: University Hospital, Gasthuisberg

This content was sourced from clinicaltrials.gov