Comparison of the Effects of the Interaction of Methylprednisolone and Dexamethasone With Sugammadex on Rocuronium Reversal Time, Postoperative Pain, and Nausea in Pediatric Patients: A Randomized Controlled Trial

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This randomized controlled trial aims to compare the interaction of methylprednisolone and dexamethasone with sugammadex in pediatric patients undergoing adenoidectomy and/or tonsillectomy. The primary objective is to evaluate the effect of these corticosteroids on the reversal time of rocuronium-induced neuromuscular block by sugammadex. Secondary outcomes include postoperative pain, nausea and vomiting, extubation time, and adverse events. Eligible participants are children aged 5 to 12 years, ASA I-II, scheduled for elective surgery under general anesthesia. The study is designed as a triple-blind, parallel-group trial with three arms: methylprednisolone, dexamethasone, and placebo.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 5
Maximum Age: 12
Healthy Volunteers: f
View:

• Children aged 5-12 years

• American Society of Anesthesiologists (ASA) physical status I-II

Locations
Other Locations
Turkey
Bezmialem Vakıf Univerisity Dragos Hospital
RECRUITING
Istanbul
Konya City Hospital
NOT_YET_RECRUITING
Konya
Contact Information
Primary
MUSTAFA BÜYÜKCAVLAK
mustafabcavlak@gmail.com
+905064733392
Time Frame
Start Date: 2025-09-16
Estimated Completion Date: 2025-12-30
Participants
Target number of participants: 60
Treatments
Experimental: Methylprednisolone
Patients will receive intravenous methylprednisolone 1 mg/kg at the induction of anesthesia.
Experimental: Dexamethasone
Patients will receive intravenous dexamethasone 0.2 mg/kg at the induction of anesthesia
Placebo_comparator: Control
Patients will receive 5 ml of intravenous normal saline at the induction of anesthesia
Related Therapeutic Areas
Sponsors
Leads: Konya City Hospital

This content was sourced from clinicaltrials.gov