• Able to understand and sign an informed consent form

• Presence of clinical indication for percutaneous coronary intervention (PCI) and/or stent placement

• Subjects willing to comply with all research and follow-up requirements.

• Angiographic criteria (ONE of the following criteria MUST be met)

‣ Target lesions visually have at least moderate calcifications\*

⁃ Target lesion balloon dilatation failure

⁃ Inability of devices (microcatheters, balloons or stents) to pass through the target lesion.

• Procedural criteria

‣ All patients treated with RA with or without other forms of debulking therapy

∙ Moderate calcification is defined as radio-opacities noted only during cardiac cycle prior to contrast injection whereas severe calcification is defined as radio-opacities seen without cardiac motion prior to contrast injection, usually affecting both sides of the arterial lumen.