Drug-Coated Balloon Versus Drug-eluting Stent Angioplasty for Treatment of Chronic Total Occlusion
Chronic total occlusion (CTO) remains one of the most challenging lesions in coronary artery disease management. Percutaneous coronary intervention using drug-eluting stents is currently a standard treatment approach; however, drug-coated balloon angioplasty has emerged as a potential alternative strategy. This study aims to compare the clinical and angiographic outcomes of drug-coated balloon angioplasty versus drug-eluting stent implantation in patients undergoing percutaneous coronary intervention for chronic total occlusion. The study will include adult patients diagnosed with CTO who meet the predefined eligibility criteria. Outcomes related to procedural success and follow-up results will be evaluated to assess the effectiveness of both treatment strategies.
• • Definite or probable CTO as per CTO-ARC definition
‣ CTO length ≥ 20 mm and ≤ 40 mm;
⁃ High likelihood (≥90 %) of CTO-PCI success (balance between CTO lesion complexity and operator expertise);
⁃ Successful treatment of any non-CTO lesions at least 1 month before randomization;
⁃ CTO lesion location in a vessel segment with diameter ≥ 2.5 mm;
⁃ Successful intraplaque (intraluminal) wiring (extraplaque tracking \< 10 mm or \< 50% of occlusion length) with no flow-limiting dissection and a TIMI flow ≥ 2 after initial predilation with NC balloon.