Functional Evaluation of Modified Studer and Modified Spiral Orthotopic Ileal Neobladders After Radical Cystectomy.

Status: Unknown
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Bladder cancer is the most common malignant neoplasm of the urinary system. Neoadjuvant chemotherapy followed by radical cystectomy (RC) is the standard treatment for Muscle invasive bladder cancer. Studer neobladder is one of the commonly used techniques for orthotopic reconstruction, originally utilizing 60-65 cm of the ileum. However, this leads to formation of a flaccid reservoir. Nowadays, most techniques use 40-45 cm ileal segment only due to the proven increased reservoir capacity over time. So Moeen et al developed a modified Studer ileal neobladder by using a shorter ileal segment (40 cm only). Upper urinary tract protection is important in neobladder reconstruction. One of the proposed anti-reflux techniques is using an isoperistaltic limp which was about 20 cm. This segment will be compressed by the elevated intra-abdominal pressure during Valsalva voiding to prevent reflux. However, this length was subjected to multiple reductions in multiple studies. Moeen et al used an 8 cm straight isoperistaltic ileal chimney. In spiral neobladder the ureters are implanted into the reservoir using a non-refluxing split-cuff nipple technique. It has good functional and urodynamic parameters. Moeen et al added 8 cm as RT sided angled chimney over the neobladder. The ureters were implanted directly in an end to side manner. They assumed that adding this angulation to this short chimney decreases reflux and protect the UUT, without adding time to develop an anti-reflux technique.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• Patients with muscle invasive bladder cancer (T2-3N0-1M0).

• Patients with T1 high grade bladder cancer with failed intravesical immunotherapy.

• Bladder neck area including the trigone free from cancerous involvement.

• Patients accepting the operation who are medically fit.

Locations
Other Locations
Egypt
Assuit university
Asyut
Contact Information
Primary
Abdelrahman Atef Ali, master degree
Abdelrahman_atefuro93@yahoo.com
00201000318832
Backup
Diaa A Sayed, PhD
diaa_hameed@hotmail.com
01203888849
Time Frame
Start Date: 2023-01-01
Completion Date: 2024-12-15
Participants
Target number of participants: 52
Treatments
Experimental: modified Studer ileal neobladder
the segment of the iso-peristaltic segment is 8 cm and the total length of the ileum used is 40 cm instead of 60 cm.
Experimental: modified spiral ileal neobladder
the chimney of the spiral neobladder will be an angled one instead of straight.
Sponsors
Leads: Assiut University

This content was sourced from clinicaltrials.gov