Efficacy and Safety of Autologous Fecal Bacteria Transplantation in Preventing Acute Graft Versus Host Disease After Haploidentical Hematopoietic Stem Cell Transplantation: a Multicenter, Open, Randomized Controlled Clinical Study
Who is this study for? Patients with Graft Vs Host Disease
What treatments are being studied? Autologous Fecal Bacteria
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
To evaluation the efficacy and safety of autologous fecal bacteria transplantation in preventing acute graft versus host disease after haploidentical hematopoietic stem cell transplantation. Bone marrow transplant patients were recruited.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: f
View:
• Haplo-HSCT patients; Bacteroidetes \>0.1%; inverse Simpson diversity ≥2
Locations
Other Locations
China
Ye Zhao
RECRUITING
Suzhou
Time Frame
Start Date: 2021-03-01
Estimated Completion Date: 2026-03-01
Participants
Target number of participants: 100
Treatments
Experimental: with auto-FMT
The patients in the experimental group took autologous fecal bacteria capsule about 3 weeks after bone marrow transplantation.
No_intervention: empty capsule
The patients in this group took empty capsule about 3 weeks after bone marrow transplantation
Related Therapeutic Areas
Sponsors
Leads: The First Affiliated Hospital of Soochow University