Patient Perception of Pain Following Extraction and Bone Graft Surgery With or Without Preemptive Ibuprofen: A Randomized Clinical Trial

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The goal of this randomized clinical trial is to compare patient-reported pain and oral health-related quality of life during the first postoperative week following extraction and bone graft surgery in patients who received preemptive ibuprofen versus placebo. Participants will receive ibuprofen 600mg or placebo by mouth with water 1 hour prior to extraction and bone graft surgery. The primary question it aims to answer is: • Does preemptive ibuprofen have an effect on postoperative pain 1 hour following extraction and bone graft surgery compared to placebo? Secondary questions are: * Does preemptive ibuprofen have an effect on pain during the first 3 postoperative hours and 7 postoperative days following extraction and bone graft surgery compared to placebo? * Does preemptive ibuprofen have an effect on oral health-related quality of life during the 7 postoperative days following extraction and bone graft surgery compared to placebo?

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Age \>18 years

• Good general health (controlled conditions)

• Fluent in English

• Treatment-planned for single site extraction and bone graft surgery

Locations
United States
Wisconsin
Marquette University School of Dentistry Graduate Periodontics Clinic
RECRUITING
Milwaukee
Contact Information
Primary
Vrisiis Kofina, DDS, MS
vrisiis.kofina@marquette.edu
516-817-0393
Backup
Christos Gousias, DDS
christos.gousias@marquette.edu
414-229-8875
Time Frame
Start Date: 2023-10-19
Estimated Completion Date: 2026-12
Participants
Target number of participants: 50
Treatments
Experimental: Ibuprofen group or Test Group
Subjects will be given ibuprofen 600mg tab 1h prior to surgery.
Placebo_comparator: Placebo group or Control group
Subjects will be given a placebo tab 1h prior to surgery.
Related Therapeutic Areas
Sponsors
Leads: Marquette University

This content was sourced from clinicaltrials.gov