Comparison of Freeze-dried Bone Allograft and Autogenous Bone Blocks in the Surgical Reconstruction of Horizontally Atrophied Jaws for Implant Placement: Randomized Clinical Trial

Status: Recruiting
Location: See location...
Intervention Type: Procedure, Diagnostic test, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

After tooth loss, the alveolar ridge undergoes various modeling and remodeling processes, resulting in overall bone resorption. In case of extensive alveolar atrophy, bone volume must be restored before or during implant placement to achieve successful dental rehabilitation and maximize implant survival and success rates. One possible method for reconstructing severe bone resorption is block bone augmentation. Due to its biological properties, autologous bone is considered the gold standard among bone graft materials, as it possesses osteoinductive, osteoconductive, and osteogenic properties. The advantages of using allografts over autologous bone grafts include reduced postoperative morbidity, decreased surgical time, and the absence of anatomical limitations regarding the amount of bone that can be harvested. The disadvantage of allografts is the loss of viable osteogenic cells and osteoinductive factors during processing. The aim of the study is: * to compare the success of the bone augmentation surgery depending on whether freeze-dried bone allograft blocks or autologous bone blocks are used, * compare the microarchitecture of the augmented bone depending on the bone graft material applied, * to evaluate the success of dental implants placed in the augmented bone and that of the prostheses delivered on the dental implants.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• over 18 years old

• require lateral augmentation for implant rehabilitation

Locations
Other Locations
Hungary
Semmelweis University Department of Public Dental Health
RECRUITING
Budapest
Contact Information
Primary
Csilla Szerencse, DMD, MDS
szerencse.csilla@semmelweis.hu
003614591500
Backup
Márton Kivovics, DMD, MDS, PHD
kivovics.marton@semmelweis.hu
003614591500
Time Frame
Start Date: 2025-09-29
Estimated Completion Date: 2033-09-01
Participants
Target number of participants: 30
Treatments
Experimental: Freeze-dried allograft bone block
A freeze-dried bone allograft block is used for the lateral augmentation of the atrophied jaw.
Active_comparator: Autogenous bone block
An autogenous bone block harvested from the retromolar area of the mandible is used for the lateral augmentation of the atrophied jaw.
Related Therapeutic Areas
Sponsors
Leads: Semmelweis University

This content was sourced from clinicaltrials.gov