Co-transplantation of Mesenchymal Stromal Cells in Allogeneic Hematopoietic Stem Cell Transplantation
Who is this study for? Patients with Graft versus Host Disease
What treatments are being studied? Cotransplant with Mesenchymal Stem Cells
Status: Recruiting
Location: See location...
Intervention Type: Biological
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY
Mesenchymal stem cells (MSCs) are known to exhibit immunomodulatory, anti-inflammatory, and pro-angiogenic properties, and therefore have the potential to improve the outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT) .The study is aimed to identify and evaluate the potential benefits of MSCs infusion during allogeneic HSCT, with regard to the engraftment, graft versus host disease (GVHD), post-transplant relapse and survival.
Eligibility
Participation Requirements
Sex: All
Maximum Age: 65
Healthy Volunteers: f
View:
• Signed written informed consent
• Aged \<65 years
• Willing to transplant
• Cardiac: Left ventricular ejection fraction ≥ 50%
• Adequate renal and hepatic function
• Performance status: Karnofsky ≥ 70%
Locations
Other Locations
China
Union Hospital,Fujian Medical University
RECRUITING
Fuzhou
Contact Information
Primary
Ting Yang, Prof.
yang.hopeting@gmail.com
+86-591-86218041
Time Frame
Start Date: 2020-02-01
Estimated Completion Date: 2025-12-01
Participants
Target number of participants: 120
Treatments
No_intervention: HSC
Experimental: MSC+HSC
Related Therapeutic Areas
Sponsors
Leads: Fujian Medical University