Ocular Graft-Versus-Host-Disease After Allogeneic Haematopoietic Stem Cell Transplantation: A Territory-Wide Prospective Cohort

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Allogeneic Haematopoietic stem cell transplantation (HSCT) is an effective treatment for all array of blood or blood-producing organ disorders. Graft-versus-host-disease (GVHD) occurs as a result of an overactive immunological system against normal host tissues. It can happen in the liver, skin, mucosal surface of the eye, gastrointestinal tract, and genitalia. Ocular GVHD occurs in 30-70% of patients after HSCT. It mainly affects the ocular surface, including the conjunctiva and cornea. In severe cases, multiple clinical manifestations can lead to painful non-healing corneal ulcers, secondary infections, and visual loss. oGVHD can be debilitating and severely impact patients' quality of life. However, there are no widely accepted guidelines available for prevention and management. In collaboration with the Department of Haematology of Queen Mary Hospital, the investigators set out to establish a territory-wide cohort of patients receiving HSCT. Primarily, the investigators aim to establish the population-based epidemiology of oGVHD and understand the natural history and the long-term ophthalmic outcomes of oGVHD via this study.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Patient aged 18 or above

• Underwent allogeneic HSCT in QMH in the two-year recruitment period

Locations
Other Locations
Hong Kong Special Administrative Region
Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong
RECRUITING
Hong Kong
Contact Information
Primary
Allie Lee
aleeni@hku.hk
+852 39621405
Backup
Alex HS Kan
alexkhs@connect.hku.hk
Time Frame
Start Date: 2021-04-30
Estimated Completion Date: 2028-10
Participants
Target number of participants: 500
Treatments
Post-Haematopoietic Stem Cell Transplantation (Post-HSCT) patients
* Patient aged 18 or above~* Underwent allogeneic HSCT in Queen Mary Hospital(QMH) in the two-year recruitment period
Family Control Subjects
The research team will invite an accompanying family member to be the family control. Microbiome and tear samples will be collected for comparison. The sample collection schedule is the same as the corresponding post-HSCT case.
Sponsors
Leads: The University of Hong Kong

This content was sourced from clinicaltrials.gov