A Phase 3 Randomized Study Comparing Teclistamab in Combination With Daratumumab SC and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab SC and Lenalidomide (Tal-DR) Versus Daratumumab SC, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma Who Are Either Ineligible or Not Intended for Autologous Stem Cell Transplant as Initial Therapy
Status: Recruiting
Location: See all (264) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The purpose of this study is to compare the efficacy of teclistamab in combination with daratumumab and lenalidomide (Tec-DR) and talquetamab in combination with daratumumab and lenalidomide (Tal-DR) versus daratumumab, lenalidomide, dexamethasone (DRd).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Have a diagnosis of multiple myeloma according to the International Myeloma Working Group (IMWG) diagnostic criteria
• Be newly diagnosed and not considered a candidate for high-dose chemotherapy with autologous stem cell transplant (ASCT) due to: ineligible due to advanced age OR; ineligible due to the presence of comorbid condition(s) likely to have a negative impact on tolerability of high-dose chemotherapy with ASCT OR; deferral of high-dose chemotherapy with ASCT as initial treatment
• Have an Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 2
• A participant must agree not to be pregnant, breastfeeding, or planning to become pregnant while enrolled in this study or within 6 months after the last dose of study treatment
• A participant must agree not to plan to father a child while enrolled in this study or within 100 days after the last dose of study treatment
Locations
United States
Arizona
Banner MD Anderson Cancer Center
RECRUITING
Gilbert
University of Arizona Cancer Center
RECRUITING
Tucson
California
UCSF Fresno
RECRUITING
Clovis
City of Hope Duarte
RECRUITING
Duarte
City of Hope Orange County Lennar Foundation Cancer Center
RECRUITING
Irvine
Cancer and Blood Specialty Clinic
RECRUITING
Los Alamitos
Valkyrie Clinical Trials
RECRUITING
Los Angeles
Connecticut
University of Connecticut
RECRUITING
Farmington
Yale New Haven Hospital
RECRUITING
New Haven
Delaware
ChristianaCare Helen F Graham Cancer Center and Research Institute
RECRUITING
Newark
Florida
Memorial Healthcare System
RECRUITING
Hollywood
AdventHealth Medical Group Blood & Marrow Transplant at Orlando
RECRUITING
Orlando
Cleveland Clinic Florida
RECRUITING
Weston
Georgia
City of Hope Cancer Center
RECRUITING
Newnan
Iowa
University of Iowa Health Care
RECRUITING
Waukee
Illinois
University Of Illinois Medical Center
RECRUITING
Chicago
Loyola University Medical Center
RECRUITING
Maywood
Kentucky
Norton Cancer Institute
RECRUITING
Louisville
Louisiana
LSUHSC Shreveport Feist-Weiller Cancer Center
RECRUITING
Shreveport
Maryland
Johns Hopkins University School of Medicine JHUSOM
RECRUITING
Baltimore
Center for Cancer and Blood Disorders
RECRUITING
Bethesda
Michigan
University of Michigan
RECRUITING
Ann Arbor
Henry Ford Cancer - Detroit Brigitte Harris Cancer Pavilion
RECRUITING
Detroit
Cancer And Hematology Centers of Western Michigan PC
RECRUITING
Grand Rapids
Henry Ford Providence Novi Hospital
RECRUITING
Novi
Henry Ford Providence Southfield CK Potluri Cancer Center
RECRUITING
Southfield
Missouri
MidAmerica Cancer Care
RECRUITING
Kansas City
North Carolina
Levine Cancer Institute
RECRUITING
Charlotte
Novant Health
RECRUITING
Charlotte
Durham VAMC
RECRUITING
Durham
Novant Health Zimmer Cancer Institute
RECRUITING
Wilmington
Atrium Health Wake Forest Baptist Comprehensive Cancer Center
RECRUITING
Winston-salem
Novant Health Forsyth Medical Center
RECRUITING
Winston-salem
Nebraska
Nebraska Cancer Specialists
RECRUITING
Omaha
University of Nebraska Medical Center
RECRUITING
Omaha
New Hampshire
Dartmouth Hitchcock Medical Center
RECRUITING
Lebanon
New Jersey
Astera Cancer Care
RECRUITING
East Brunswick
New Mexico
Christus St. Vincent Regional Cancer Center
RECRUITING
Santa Fe
New York
Hematology-Oncology Associates of CNY
RECRUITING
East Syracuse
Northwell Health Cancer Institute
RECRUITING
Lake Success
NYU Langone Hospital Long Island
RECRUITING
Mineola
Memorial Sloan Kettering Cancer Center
RECRUITING
New York
Perlmutter Cancer Center at NYU Langone Health
RECRUITING
New York
Weill Cornell Medical College
RECRUITING
New York
Ohio
Oncology Hematology Care
RECRUITING
Cincinnati
The Christ Hospital Cancer Center
RECRUITING
Cincinnati
University of Cincinnati
RECRUITING
Cincinnati
Cleveland Clinic Main Campus
RECRUITING
Cleveland
University Hospitals Cleveland Medical Center
RECRUITING
Cleveland
OhioHealth
RECRUITING
Columbus
The Ohio State University- James Cancer Hospital
RECRUITING
Columbus
Pennsylvania
Penn State Milton S Hershey Medical Ctr
RECRUITING
Hershey
Allegheny Health Network
RECRUITING
Pittsburgh
Rhode Island
Rhode Island Hospital
RECRUITING
Providence
South Carolina
MUSC-Hollings Cancer Center
RECRUITING
Charleston
Tennessee
Henry-Joyce Cancer Clinic
RECRUITING
Nashville
Texas
University of Texas Southwestern Medical Center
RECRUITING
Dallas
Houston Methodist Hospital
RECRUITING
Houston
Joe Arrington Cancer Research Treatment Center
RECRUITING
Lubbock
Utah
Huntsman Cancer Institute
RECRUITING
Salt Lake City
Utah Cancer Specialists
RECRUITING
Salt Lake City
Virginia
University of Virginia
COMPLETED
Charlottesville
Alexander T. Augusta Military Medical Center
RECRUITING
Fort Belvoir
Virginia Oncology Associates Brock Cancer Center
RECRUITING
Norfolk
Richmond VA Medical Center
RECRUITING
Richmond
Virginia Commonwealth University Medical Center
RECRUITING
Richmond
Washington
NorthWest Medical Specialties, PLLC
RECRUITING
Tacoma
Other Locations
Australia
Royal Prince Alfred Hospital
ACTIVE_NOT_RECRUITING
Camperdown
Barwon Health - University Hospital Geelong
ACTIVE_NOT_RECRUITING
Geelong
Liverpool Hospital
ACTIVE_NOT_RECRUITING
Liverpool
Sir Charles Gairdner Hospital
ACTIVE_NOT_RECRUITING
Nedlands
Calvary Mater Newcastle Hospital
ACTIVE_NOT_RECRUITING
New South Wales
Wollongong Hospital
ACTIVE_NOT_RECRUITING
Wollongong
Princess Alexandra Hospital
ACTIVE_NOT_RECRUITING
Woolloongabba
Austria
Ordensklinikum Linz GmbH Elisabethinen
ACTIVE_NOT_RECRUITING
Linz
SCRI CCCIT gem GmbH
ACTIVE_NOT_RECRUITING
Salzburg
Hanusch Krankenhaus
ACTIVE_NOT_RECRUITING
Vienna
Medical University Vienna
ACTIVE_NOT_RECRUITING
Vienna
Belgium
Institut Jules Bordet
RECRUITING
Anderlecht
ZAS Augustinus
COMPLETED
Antwerp
ZAS Cadix
RECRUITING
Antwerp
Ghent University Hospital
RECRUITING
Ghent
Jolimont
COMPLETED
Haine Saint Paul La Louviere
Az Groeninge
RECRUITING
Kortrijk
Universitair Ziekenhuis Leuven
RECRUITING
Leuven
Brazil
Fundacao Pio XII
COMPLETED
Barretos
Santa Casa de Misericordia de Belo Horizonte
ACTIVE_NOT_RECRUITING
Belo Horizonte
Hospital Erasto Gaertner- Liga Paranaense de Combate ao Cancer
ACTIVE_NOT_RECRUITING
Curitiba
Instituto Do Cancer Do Ceara
ACTIVE_NOT_RECRUITING
Fortaleza
Liga Norte Riograndense Contra O Cancer
ACTIVE_NOT_RECRUITING
Natal
Complexo Hospitalar de Niteroi
ACTIVE_NOT_RECRUITING
Niterói
Hospital De Clinicas De Porto Alegre
ACTIVE_NOT_RECRUITING
Porto Alegre
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto
ACTIVE_NOT_RECRUITING
Ribeirão Preto
IDOR - Regional Bahia
ACTIVE_NOT_RECRUITING
Salvador
Clinica Medica Sao Germano LTDA
ACTIVE_NOT_RECRUITING
São Paulo
Hospital Das Clinicas Da Faculdade De Medicina Da USP
ACTIVE_NOT_RECRUITING
São Paulo
Hospital Nove de Julho
ACTIVE_NOT_RECRUITING
São Paulo
Canada
Arthur J E Child Comprehensive Cancer Centre
ACTIVE_NOT_RECRUITING
Calgary
Cross Cancer Institute
COMPLETED
Edmonton
Lakeridge Health Oshawa
RECRUITING
Oshawa
CHU de Quebec L Hotel Dieu de Quebec
ACTIVE_NOT_RECRUITING
Québec
British Columbia Cancer Agency
ACTIVE_NOT_RECRUITING
Vancouver
China
Beijing Tongren Hospital CMU
ACTIVE_NOT_RECRUITING
Beijing
Peking Union Medical College Hospital
ACTIVE_NOT_RECRUITING
Beijing
Peking University First Hospital
ACTIVE_NOT_RECRUITING
Beijing
The First Hospital of Jilin University
ACTIVE_NOT_RECRUITING
Changchun
The Second Xiangya Hospital of Central South Hospital
ACTIVE_NOT_RECRUITING
Changsha
Changzhou No 2 Peoples Hospital
ACTIVE_NOT_RECRUITING
Changzhou
Beijing Chaoyang Hospital
ACTIVE_NOT_RECRUITING
Chaoyang District
Sichuan Provincial Peoples Hospital
ACTIVE_NOT_RECRUITING
Chengdu
Chongqing University Cancer Hospital
ACTIVE_NOT_RECRUITING
Chongqing
Fujian Meidical University Union Hospital
ACTIVE_NOT_RECRUITING
Fuzhou
Nanfang Hospital
ACTIVE_NOT_RECRUITING
Guangzhou
Sun Yat -Sen University Cancer Center
ACTIVE_NOT_RECRUITING
Guangzhou
No.1 Affiliated Hospital, Medical College of Zhejiang University
ACTIVE_NOT_RECRUITING
Hangzhou
The Second Affiliated Hospital of Zhejiang University
ACTIVE_NOT_RECRUITING
Hangzhou
Harbin medical university cancer hospital
COMPLETED
Harbin
Qilu Hospital of Shandong University
COMPLETED
Jinan
The First Affliated Hospital Of Nanchang University
ACTIVE_NOT_RECRUITING
Nanchang
Nanjing Drum Tower Hospital
ACTIVE_NOT_RECRUITING
Nanjing
Zhongda Hospital Southeast University
ACTIVE_NOT_RECRUITING
Nanjing
The First Affiliated Hospital of Guangxi Medical University
ACTIVE_NOT_RECRUITING
Nanning
Renji Hospital, Shanghai Jiaotong University School of Medicine
ACTIVE_NOT_RECRUITING
Shanghai
Ruijin Hospital Shanghai Jiao Tong University
ACTIVE_NOT_RECRUITING
Shanghai
Shanghai Fourth People s Hospital
ACTIVE_NOT_RECRUITING
Shanghai
Shengjing Hospital Of China Medical University
ACTIVE_NOT_RECRUITING
Shenyang
Peking University Shenzhen Hospital
ACTIVE_NOT_RECRUITING
Shenzhen
Institute of Hematology and Blood Diseases Hospital
ACTIVE_NOT_RECRUITING
Tianjin
Tianjin Medical University Cancer Institute and Hospital
ACTIVE_NOT_RECRUITING
Tianjin
The First Affiliated Hospital of Wenzhou Medical University
ACTIVE_NOT_RECRUITING
Wenzhou
Wuhan Tongji Hospital Tongji Medical College
ACTIVE_NOT_RECRUITING
Wuhan
The Second Affiliated Hospital of Xi'an Jiaotong University
ACTIVE_NOT_RECRUITING
Xi'an
The first affiliated hospital of xiamen university
ACTIVE_NOT_RECRUITING
Xiamen
Henan Cancer Hospital
ACTIVE_NOT_RECRUITING
Zhengzhou
Denmark
Aalborg University Hospital
ACTIVE_NOT_RECRUITING
Aalborg
Regionshospitalet Godstrup
ACTIVE_NOT_RECRUITING
Herning
Zealand University Hospital
ACTIVE_NOT_RECRUITING
Roskilde
Vejle Sygehus
ACTIVE_NOT_RECRUITING
Vejle
France
CHU Henri Mondor
RECRUITING
Créteil
Hopital Claude Huriez
ACTIVE_NOT_RECRUITING
Lille
Hospices Civils de Lyon HCL
ACTIVE_NOT_RECRUITING
Lyon
CHU Nantes
ACTIVE_NOT_RECRUITING
Nantes
CHU Hopital Saint Antoine
COMPLETED
Paris
CHU de Bordeaux - Hospital Haut-Leveque
ACTIVE_NOT_RECRUITING
Pessac
CHU Poitiers - Hopital la Miletrie
ACTIVE_NOT_RECRUITING
Poitiers
CHU de Rennes - Hopital Pontchaillou
ACTIVE_NOT_RECRUITING
Rennes
Hôpitaux Universitaires de Strasbourg - Hôpital de Hautepierre
ACTIVE_NOT_RECRUITING
Strasbourg
Institut Universitaire du Cancer Toulouse Oncopole
ACTIVE_NOT_RECRUITING
Toulouse
Germany
Helios Kliniken Berlin Buch Gmbh
ACTIVE_NOT_RECRUITING
Berlin
Med. Universitatsklinik Essen
RECRUITING
Essen
Universitaetsklinikum Halle Saale
ACTIVE_NOT_RECRUITING
Halle
Universitaetsklinik Hamburg-Eppendorf
ACTIVE_NOT_RECRUITING
Hamburg
Klinikum Nuernberg Nord
ACTIVE_NOT_RECRUITING
Nuremberg
Universitaetsklinikum Tuebingen der Eberhard-Karls-Universitaet, Abteilung fuer Innere Medizin II,
ACTIVE_NOT_RECRUITING
Tübingen
Universitaetsklinikum Wuerzburg
ACTIVE_NOT_RECRUITING
Würzburg
Greece
Alexandra General Hospital of Athens
ACTIVE_NOT_RECRUITING
Athens Attica
Theageneio Cancer Hospital
ACTIVE_NOT_RECRUITING
Thessaloniki
G Papanikolaou Hospital of Thessaloniki
ACTIVE_NOT_RECRUITING
Thessalonikis
Israel
Soroka Medical Center
ACTIVE_NOT_RECRUITING
Beersheba
Rambam Medical Center
ACTIVE_NOT_RECRUITING
Haifa
Shaare Zedek Medical Center
ACTIVE_NOT_RECRUITING
Jerusalem
Rabin
ACTIVE_NOT_RECRUITING
Petah Tikva
Sheba Medical Center
ACTIVE_NOT_RECRUITING
Ramat Gan
Tel Aviv Sourasky Medical Center
ACTIVE_NOT_RECRUITING
Tel Aviv
Italy
ASST Papa Giovanni XXIII Bergamo
RECRUITING
Bergamo
A O U Sant Orsola Malpighi
RECRUITING
Bologna
Careggi University Hospital
RECRUITING
Florence
Ospedale San Raffaele
RECRUITING
Milan
Azienda Ospedaliera di Rilievo Nazionale A Cardarelli
RECRUITING
Naples
IRCCS Policlinico San Matteo, Università degli studi di Pavi
RECRUITING
Pavia
Universita Degli Studi di Roma Tor Vergata
RECRUITING
Roma
Istituto Clinico Humanitas
RECRUITING
Rozzano
Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino
RECRUITING
Torino
Japan
Juntendo University Hospital
ACTIVE_NOT_RECRUITING
Bunkyō City
Chiba Cancer Center
ACTIVE_NOT_RECRUITING
Chiba
Kameda Medical Center
ACTIVE_NOT_RECRUITING
Chiba
National Hospital Organization Mito Medical Center
ACTIVE_NOT_RECRUITING
Higashiibaraki-gun
Kansai Medical University Hospital
ACTIVE_NOT_RECRUITING
Hirakata
Hyogo Medical University Hospital
ACTIVE_NOT_RECRUITING
Hyôgo
Saitama Medical University Hospital
ACTIVE_NOT_RECRUITING
Iruma-gun
Tokai University Hospital
ACTIVE_NOT_RECRUITING
Kanagawa
Kanazawa University Hospital
ACTIVE_NOT_RECRUITING
Kanazawa
Kumamoto University Hospital
ACTIVE_NOT_RECRUITING
Kumamoto
Matsuyama Red Cross Hospital
ACTIVE_NOT_RECRUITING
Matsuyama
National Hospital Organization Nagasaki Medical Center
ACTIVE_NOT_RECRUITING
Nagasaki
National Hospital Organization Okayama Medical Center
ACTIVE_NOT_RECRUITING
Okayama
Osaka Metropolitan University Hospital
ACTIVE_NOT_RECRUITING
Osaka
National Hospital Organization Hokkaido Cancer Center
ACTIVE_NOT_RECRUITING
Sapporo
National Hospital Organization Shibukawa Medical Center
ACTIVE_NOT_RECRUITING
Shibukawa
Japanese Red Cross Medical Center
ACTIVE_NOT_RECRUITING
Shibuya-ku
Shizuoka Cancer Center
ACTIVE_NOT_RECRUITING
Sunto Gun
Fujita Health University Hospital
ACTIVE_NOT_RECRUITING
Toyoake
Yamagata University Hospital
ACTIVE_NOT_RECRUITING
Yamagata
Yamanashi Prefectural Central Hospital
ACTIVE_NOT_RECRUITING
Yamanashi
Netherlands
VUMC Amsterdam
RECRUITING
Amsterdam
Gelre Ziekenhuis
RECRUITING
Apeldoorn
Reinier de Graaf Gasthuis
RECRUITING
Delft
St. Antonius Ziekenhuis Nieuwegein
RECRUITING
Nieuwegein
Zuyderland Medical Center
RECRUITING
Sittard-geleen
Norway
Oslo University Hospital HF Ulleval sykehus
ACTIVE_NOT_RECRUITING
Oslo
St. Olavs Hospital
ACTIVE_NOT_RECRUITING
Trondheim
Poland
Wojewodzki Szpital Kliniczny w Bialej Podlaskiej
COMPLETED
Biała Podlaska
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza
ACTIVE_NOT_RECRUITING
Brzozów
Szpital Uniwersytecki nr 2 im. Jana Biziela w Bydgoszczy
ACTIVE_NOT_RECRUITING
Bydgoszcz
Pratia Onkologia Katowice
ACTIVE_NOT_RECRUITING
Katowice
Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach
ACTIVE_NOT_RECRUITING
Kielce
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im M Kopernika w Lodzi
ACTIVE_NOT_RECRUITING
Lodz
Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli
ACTIVE_NOT_RECRUITING
Lublin
Uniwersytecki Szpital Kliniczny Nr 1 w Lublinie
ACTIVE_NOT_RECRUITING
Lublin
Uniwersytecki Szpital Kliniczny w Poznaniu
ACTIVE_NOT_RECRUITING
Poznan
Uniwersyteckie Centrum Kliniczne
ACTIVE_NOT_RECRUITING
Warsaw
Szpital Uniwersytecki im Karola Marcinkowskiego w Zielonej Gorze
COMPLETED
Zielona Góra
Portugal
Uls Braga - Hosp. Braga
ACTIVE_NOT_RECRUITING
Braga
Champalimaud Foundation Champalimaud Centre
ACTIVE_NOT_RECRUITING
Lisbon
Instituto Portugues de Oncologia do Porto Francisco Gentil, E.P.E.
ACTIVE_NOT_RECRUITING
Porto
Uls Hosp Sao Joao
ACTIVE_NOT_RECRUITING
Porto
Republic of Korea
Dong-A University Hospital
ACTIVE_NOT_RECRUITING
Busan
Pusan National University Hospital
ACTIVE_NOT_RECRUITING
Busan
Kyungpook National University Hospital
ACTIVE_NOT_RECRUITING
Daegu
National Cancer Center
ACTIVE_NOT_RECRUITING
Goyang-si
Chonnam National University Hwasun Hospital
ACTIVE_NOT_RECRUITING
Hwasun
Gachon University Gil Medical Center
ACTIVE_NOT_RECRUITING
Incheon
Asan Medical Center
ACTIVE_NOT_RECRUITING
Seoul
Samsung Medical Center
ACTIVE_NOT_RECRUITING
Seoul
Seoul National University Hospital
ACTIVE_NOT_RECRUITING
Seoul
Severance Hospital Yonsei University Health System
ACTIVE_NOT_RECRUITING
Seoul
The Catholic University of Korea Seoul St Mary s Hospital
ACTIVE_NOT_RECRUITING
Seoul
Spain
Hosp. Univ. Germans Trias I Pujol
ACTIVE_NOT_RECRUITING
Badalona
Hosp Univ Vall D Hebron
ACTIVE_NOT_RECRUITING
Barcelona
Hosp. de La Santa Creu I Sant Pau
ACTIVE_NOT_RECRUITING
Barcelona
Institut Catala d Oncologia L Hospitalet
ACTIVE_NOT_RECRUITING
Barcelona
Hosp. Univ. Virgen de Las Nieves
ACTIVE_NOT_RECRUITING
Granada
Hosp. de Jerez de La Frontera
ACTIVE_NOT_RECRUITING
Jerez De La Frontera
Hosp Univ Hm Sanchinarro
ACTIVE_NOT_RECRUITING
Madrid
Hosp. Univ. 12 de Octubre
ACTIVE_NOT_RECRUITING
Madrid
Hosp. Univ. La Paz
ACTIVE_NOT_RECRUITING
Madrid
Hosp. Univ. Son Espases
ACTIVE_NOT_RECRUITING
Palma De Mallorca
Hosp. Quiron Madrid Pozuelo
ACTIVE_NOT_RECRUITING
Pozuelo De Alarcón
Hosp Clinico Univ de Salamanca
ACTIVE_NOT_RECRUITING
Salamanca
Hosp. Mutua Terrassa
ACTIVE_NOT_RECRUITING
Terrassa
Hosp. Clinico Univ. de Valencia
ACTIVE_NOT_RECRUITING
Valencia
Sweden
Falu Lasarett
ACTIVE_NOT_RECRUITING
Falun
Skanes universitetssjukhus
ACTIVE_NOT_RECRUITING
Lund
Universitetssjukhuset Orebro
ACTIVE_NOT_RECRUITING
Örebro
Karolinska University Hospital Huddinge
ACTIVE_NOT_RECRUITING
Stockholm
Switzerland
Inselspital Universitatsspital Bern
ACTIVE_NOT_RECRUITING
Bern
Kantonsspital St Gallen
ACTIVE_NOT_RECRUITING
Sankt Gallen
Turkey
Ankara Universitesi Tip Fakultesi Cebeci Arastirma ve Uygulama Hastanesi
ACTIVE_NOT_RECRUITING
Ankara
Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital
ACTIVE_NOT_RECRUITING
Ankara
Liv Hospital Ankara
ACTIVE_NOT_RECRUITING
Ankara
Memorial Antalya Hospital
ACTIVE_NOT_RECRUITING
Antalya
Pamukkale University Medical Faculty
COMPLETED
Denizli
Medipol Mega Universite Hastanesi
ACTIVE_NOT_RECRUITING
Istanbul
Dokuz Eylul University Medical Faculty
COMPLETED
Izmir
Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi
ACTIVE_NOT_RECRUITING
Samsun
United Kingdom
University Hospitals Birmingham NHS Foundation Trust
RECRUITING
Birmingham
Blackpool Victoria Hospital
RECRUITING
Blackpool
Bristol NHS Foundation Trust
RECRUITING
Bristol
Addenbrooke's Hospital
RECRUITING
Cambridge
Kent and Canterbury Hospital
RECRUITING
Canterbury
Western General Hospital
RECRUITING
Edinburgh
Imperial College Healthcare
RECRUITING
London
University College London Hospitals
RECRUITING
London
New Cross Hospital
RECRUITING
Wolverhampton
Contact Information
Primary
Study Contact
Participate-In-This-Study1@its.jnj.com
844-434-4210
Time Frame
Start Date: 2022-10-25
Estimated Completion Date: 2033-10-28
Participants
Target number of participants: 1590
Treatments
Experimental: Teclistamab, Daratumumab SC, and Lenalidomide (Tec-DR)
Participants will receive teclistamab as subcutaneous (SC) injection in combination with daratumumab and lenalidomide.
Experimental: Talquetamab, Daratumumab SC, and Lenalidomide (Tal-DR)
Participants will receive talquetamab as SC injection in combination with daratumumab and lenalidomide.
Active_comparator: Daratumumab SC, Lenalidomide, and Dexamethasone (DRd)
Participants will receive daratumumab as SC injection with lenalidomide and dexamethasone.
Related Therapeutic Areas
Sponsors
Leads: Janssen Research & Development, LLC