A Prospective, Multi-center, Single-arm Clinical Study to Evaluate the Safety and Efficacy of a Modified Allogeneic Hematopoietic Stem Cell Transplantation Regimen for Severe Aplastic Anemia

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

The aim of this study was to evaluate the safety and efficacy of a modified allogeneic hematopoietic stem cell transplantation regimen for aplastic anemia.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 3
Maximum Age: 65
Healthy Volunteers: t
View:

• Patients with benign or malignant hematological diseases such as leukemia, lymphoma, thalassemia, aplastic anemia, etc. diagnosed by NCCN guidelines, and requiring allogeneic hematopoietic stem cell transplantation as determined by the researchers;

• Age 3-65 years old;

• Weight 10Kg-100Kg;

• Eastern Cooperative Oncology Group (ECOG) score ≤3;

• No major organ injury (ECG ejection fraction \>45%; bilirubin \< 2 times the upper limit of normal value; AST and ALT \< 3 times the upper limit of normal value; serum creatinine \< 2 times the upper limit of normal value);

• No severe infection;

• Subjects voluntarily participated in this clinical trial and signed the informed consent.

Locations
Other Locations
China
920th Hospital of Joint Logistics Support Force of People's Liberation Army of China
RECRUITING
Kunming
Contact Information
Primary
wang PI sanbin, Doctor
Wangsanbin2022@126.com
0871-64774206
Time Frame
Start Date: 2024-03-01
Estimated Completion Date: 2027-04-01
Participants
Target number of participants: 30
Treatments
Experimental: Experimental group
Sponsors
Leads: Hematology department of the 920th hospital

This content was sourced from clinicaltrials.gov