Effects of Endotracheal Tube Cuff Pressure Management on Upper Airway Edema During Cardiopulmonary Bypass in Coronary Artery Bypass Grafting: A Double-Blind, Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study investigates how endotracheal tube (ETT) cuff pressure management during cardiopulmonary bypass (CPB) in coronary artery bypass grafting (CABG) affects upper airway edema. Patients will be randomized into two groups: cuff pressure kept at 0 mmHg or maintained at 20-30 mmHg during CPB. Ultrasonography will be used to measure lateral pharyngeal wall thickness, tongue parameters, and other airway dimensions at predefined perioperative time points. The primary outcome is the change in lateral pharyngeal wall thickness as an indicator of airway edema. A total of 76 patients aged 18-80 years undergoing elective CABG with CPB will be enrolled. The results aim to clarify safe cuff pressure management strategies to reduce airway edema.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Patients scheduled for elective coronary artery bypass grafting (CABG) surgery

• Aged 18-80 years

• ASA physical status class III-IV

• Providing written informed consent

Locations
Other Locations
Turkey
University of Health Sciences Kocaeli City Hospital
RECRUITING
İzmit
Contact Information
Primary
Engin ÇETİN
Doccetin52@gmail.com
5321206004
Time Frame
Start Date: 2025-09-24
Estimated Completion Date: 2026-01-01
Participants
Target number of participants: 76
Treatments
Active_comparator: ETT cuff pressure 0 mmHg
ETT cuff pressure will be set to 0 mmHg
Active_comparator: ETT cuff pressure 20-30 mmHg
ETT cuff pressure will be set to 20-30 mmHg
Sponsors
Leads: Engin Çetin

This content was sourced from clinicaltrials.gov