Coronary Artery Bypass Graft (CABG) Clinical Trials

Clinical trials related to Coronary Artery Bypass Graft (CABG) Procedure

Enhancement of the Recovery Profile in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery Through Combination of Multiple Regional Nerve Blocks

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

In cardiac surgery patients , effective pain control is crucial to support early extubation, mobilization, and cognitive recovery, yet systemic opioids carry substantial risks such as respiratory depression, delirium, and delayed rehabilitation. While regional fascial plane blocks offer a safer, opioid-sparing alternative, no single technique provides complete analgesia for the complex and multi-dermatomal pain generated by sternotomy, graft harvesting, chest wall retraction, and drain sites. Therefore, a multimodal approach combining blocks such as parasternal nerve block , rectus sheath nerve block and femoral nerve block , may cover most of areas expected to be sources of intraoperative and post-operative pain in cardiac surgery patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:

• o Scheduled for elective off-pump coronary artery bypass graft (OPCAB) surgery via median sternotomy

‣ American Society of Anesthesiologists (ASA) physical status III - IV

⁃ Ability to provide informed consent

Locations
Other Locations
Egypt
Ain shams university hospitals
RECRUITING
Cairo
Contact Information
Primary
Abdelrahman H Ashour
AbdelrahmanAshour@med.asu.edu.eg
+2-1010184467
Time Frame
Start Date: 2026-09-10
Estimated Completion Date: 2027-04-07
Participants
Target number of participants: 30
Treatments
Active_comparator: Group A (intervention)
Patients in this group will receive standardized general anaesthesia with a preemptive bilateral superficial parasternal nerve block using 20 mL of 0.25% bupivacaine per side, in combination with a rectus sheath block (RSB) using 10 mL of 0.25% bupivacaine per side. and femoral nerve block at the side of harvesting using 10 mL of 0.25% bupivacaine.
Placebo_comparator: Group B ( control)
Patients will receive standardized general anesthesia with placebo (saline) injections administered in the same anatomical planes.
Sponsors
Leads: Ain Shams University

This content was sourced from clinicaltrials.gov

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