Robot-assisted Cystectomy With Prostate and Seminal-sparing Technique Followed by Modified Orthotopic Ileal Neobladder

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

With the same tumor control rate as classic radical cystectomy, radical cystectomy with partial preservation of the prostate and seminal vesicle can effectively preserve penile erection and fertility, improve urinary control rate and shorten hospitalization time. In this project, transurethral resection of the prostate was used to remove part of the prostate, which further reduced the trauma of radical cystectomy and better preserved the nerves and urethral sphincter. Rapid intraoperative examination of resected tissue can provide a basis for the selection of surgical options. Robot-assisted radical cystectomy can perform pelvic lymph node dissection more accurately, preserve neurovascular complex more effectively, and improve the control effect of tumor and the protective effect of sexual function and reproductive function. In view of the shortcomings of the internationally accepted orthotopic ileal neobladder, this study improved the operation according to the physiological and anatomical characteristics, restored the orthophoria of the new bladder, maintained the consistency of physiological anatomy, and minimized the bladder pressure.

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 20
Maximum Age: 70
Healthy Volunteers: f
View:

• Muscle invasive or recurrent multiple non-muscle invasive bladder cancer patients

• Invasive bladder cancer patients without invasion of the triangle and posterior urethra

• Age \< 70 years old, urethral sphincter function is good

• Male patients with serum prostate specific antigen \< 4ug / L

Locations
Other Locations
China
Union hospital,Tongji medical college, Huazhong university of science and techonology
RECRUITING
Wuhan
Contact Information
Primary
Xiaoping Zhang
xzhang@hust.edu.cn
+86-027-85351625
Time Frame
Start Date: 2024-06-01
Estimated Completion Date: 2026-01-01
Participants
Target number of participants: 20
Treatments
Experimental: Prostate and seminal-sparing Cystectomy
Patients undergoing transurethral resection and enucleation of the prostate before robot-assisted cystectomy
Placebo_comparator: Conventional Radical Cystoprostatectomy
Patients undergoing conventional robot-assisted radical cystoprostatectomy
Related Therapeutic Areas
Sponsors
Leads: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

This content was sourced from clinicaltrials.gov