Mechanisms and Effects of Pallidal Deep Brain Stimulation on Levodopa Resistant Motor Signs in Parkinson's Disease; Udall Project 2 Aim 2A&C

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

This protocol will leverage the novel (on-label, FDA-approved) local field potential measuring capability of the Medtronic Percept™ PC DBS system to study the effects of globus pallidus internus and globus pallidus externus (GPi, GPe) DBS on: the wash-out and wash-in dynamics of motor behavior and local field potentials (LFPs) and correlations between fluctuations in gait and LFPs during activities of daily living (recorded over 4 weeks). These experiments will elucidate the relationships between GP LFPs oscillations, lower limb function, postural control and gait performance.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• Receiving DBS therapy in GP for treatment of PD

• Implanted with Medtronic Percept DBS system

• At least 3 months since initial activation of the neurostimulator

Locations
United States
Minnesota
University of Minnesota
RECRUITING
Minneapolis
Contact Information
Primary
Colum Mackinnon, PhD
cmackinn@umn.edu
612-625-8938
Time Frame
Start Date: 2023-01-01
Estimated Completion Date: 2027-03-01
Participants
Target number of participants: 36
Treatments
Participants
Inclusion criteria for all aims/experiments~* Receiving DBS therapy in GP for treatment of PD~* Implanted with Medtronic Percept DBS system~* At least 3 months since initial activation of the neurostimulator
Sponsors
Leads: University of Minnesota

This content was sourced from clinicaltrials.gov