A Neural Basis for Cognitive Decline Following Deep Brain Stimulation

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY

This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS. A total of 55 participants with Parkinson's Disease planning to undergo DBS will be recruited from MUSCs Clinical DBS Program. Participants will undergo four visits, including a 1-hour screening visit, a 1.5-hour pre-DBS MRI scanning visit, and a 3.5-hour post-DBS cognitive assessment visit. In addition control participants without Parkinson's Disease will be recruited to undergo MRI scanning and cognitive assessments.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Subjects above 18 years of age

• Subjects who will undergo DBS surgery as part of their clinical care for PD

• Subjects above 18 years of age

• Age matched to participants in PD group

Locations
United States
South Carolina
Medical University of South Carolina
RECRUITING
Charleston
Contact Information
Primary
Daniel H Lench, PhD
lenchd@musc.edu
843-792-9115
Backup
Gonzalo J Revuelta, DO
revuelta@musc.edu
843-792-7262
Time Frame
Start Date: 2023-04-01
Estimated Completion Date: 2026-03-31
Participants
Target number of participants: 80
Treatments
Parkinson's Disease undergoing DBS
This study will recruit 55 patients with Parkinson's disease (PD) participants who will undergo DBS surgery and and are scheduled for a pre-DBS neuropsychological evaluation at MUSC.
Healthy Control participants without Parkinson's Disease
This study will recruit 25 healthy controls (age-matched) to serve as a comparison of baseline cognitive and neuroimaging measures.
Sponsors
Leads: Medical University of South Carolina

This content was sourced from clinicaltrials.gov