Research on Lead Localization for Deep Brain Stimulation After Implantation

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Deep brain stimulation (DBS) is an effective treatment for a variety of neurological and psychiatric disorders, with more than 200,000 patients implanted with DBS devices worldwide. Parkinson's disease is one of the typical indications.The clinical outcomes of DBS depends on the accurate implantation of the lead, and the identification of the lead locations is the basis for evaluating the effectiveness of the treatment. The aim of this study is to localize the implantation position of the lead based on postoperative MRI images and to reconstruct the relative spatial relationship between the lead and the stimulation target. By comparing with the lead position identified based on postoperative CT, this study will evaluate the accuracy of identifying the DBS lead position directly from MRI. This study may help to optimise the stimulation parameters and investigate the best stimulation targets for DBS patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:

• Parkinson's disease patients with DBS devices, DBS implanted for at least 1 month.

• Ability to tolerate DBS turn-off for at least 30 minutes.

• DBS devices do not contain the ferromagnetic material.

• The patients can fully understand the content of the trial and sign the informed consent form.

• Able to comply to the requirements of this study.

Locations
Other Locations
China
National Engineering Research Center of Neuromodulation
RECRUITING
Beijing
Contact Information
Primary
Feng Zhang, Ph.D.
zhang-f@mail.tsinghua.edu.cn
86-010-62794952
Time Frame
Start Date: 2023-12-10
Estimated Completion Date: 2025-12
Participants
Target number of participants: 10
Treatments
Experimental: DBS lead localization
Participates will receive a head MRI anc CT scan. The stimulation target and the related neural nuclei will be reconstructed using MRI images. The spatial position of the implanted lead will be identified with MRI and CT. Through comparing with the identified lead position by CT, the accuracy of lead localization by MRI will be evaluated.
Sponsors
Leads: Tsinghua University

This content was sourced from clinicaltrials.gov