Deep Brain Stimulation Clinical Trials

Clinical trials related to Deep Brain Stimulation Procedure

Restoration of Consciousness With Ultrasonic Deep Brain Stimulation During Anesthetic Sedation

Status: Recruiting
Location: See location...
Intervention Type: Procedure, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The purpose of this study is to see if mental functions take place during different levels of anesthesia using two commonly used drug (propofol and dexmedetomidine) and will include low-intensity focused ultrasound pulsation (LIFUP) to stimulate specific areas of the brain while undergoing functional Magnetic Resonance Imaging (fMRI or brain imaging), which shows areas in the brain involved in thinking at different depths of anesthesia. That is, ultrasound is being used to stimulate the brain and multiple pictures will be taken of the brain. As a result of this study, we expect to gain a deeper understanding of mental function during different levels of anesthesia, and to evaluate if the use of ultrasonic brain stimulation accelerates return to consciousness.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 40
Healthy Volunteers: t
View:

• Healthy study participants with American Society of Anesthesiologists (ASA) Physical Status Classification System-1 status

• The participants will be right-handed adults

• Body mass index (BMI) less than 30.

• All subjects will be English speakers.

Locations
United States
Michigan
University of Michigan
RECRUITING
Ann Arbor
Contact Information
Primary
Aaron Ellis
aaronel@med.umich.edu
734-647-8129
Backup
Amy McKinney
adrongo@med.umich.edu
734-647-8129
Time Frame
Start Date: 2025-10-24
Estimated Completion Date: 2030-10
Participants
Target number of participants: 168
Treatments
Experimental: Propofol & Dorsolateral prefrontal cortex (DLPFC) pulsation
Experimental: Propofol & Anterior insular cortex (AIC) pulsation
Experimental: Propofol & Central thalamus (CT) pulsation
Experimental: Dexmedetomidine & DLPFC pulsation
Experimental: Dexmedetomidine & AIC pulsation
Experimental: Dexmedetomidine & CT pulsation
Related Therapeutic Areas
Sponsors
Leads: University of Michigan
Collaborators: National Institute of General Medical Sciences (NIGMS)

This content was sourced from clinicaltrials.gov